# Glucose patterns and cardiac arrhythmias in older adults with diabetes

> **NIH NIH R01** · JOHNS HOPKINS UNIVERSITY · 2022 · $767,658

## Abstract

Abstract
Type 2 diabetes and cardiac arrhythmias are both highly prevalent in older age. There is growing awareness
that diabetes affects the electrical conduction system in the heart. Asymptomatic arrhythmias are thought to be
particularly common in older adults, especially in the setting of diabetes. Many of these arrhythmias are
thought to be harmful, but their impact on cardiovascular outcomes and mortality in older adults with diabetes
is not clear. Prior research has shown that glycemic variability and hypoglycemia in diabetes contribute to a
high burden of atrial and ventricular arrhythmias. However, prior studies have not collected concomitant
information on glucose patterns and ECG recordings. We contend the glycemic patterns (low, high, and
variable glucose) may acutely contribute to cardiac arrhythmias in diabetes. To address this question, we will
conduct continuous glucose monitoring and leadless “patch” ECG monitoring in a population of adults with
diabetes aged 60 years and older to assess coinciding variations in glycemia and cardiac rhythm. We will
relate these patterns to current health status and long-term clinical outcomes. Our research will inform the role
of low, high, and variable glucose in leading to cardiac arrhythmias and subsequent outcomes in older adults
with diabetes.

## Key facts

- **NIH application ID:** 10360749
- **Project number:** 1R01HL158022-01A1
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** Lin Yee Chen
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $767,658
- **Award type:** 1
- **Project period:** 2022-04-01 → 2026-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10360749

## Citation

> US National Institutes of Health, RePORTER application 10360749, Glucose patterns and cardiac arrhythmias in older adults with diabetes (1R01HL158022-01A1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10360749. Licensed CC0.

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