# Phase 2 Enhancement of Outdoor Group Housing for U42 SPF 9 Rhesus Macaques

> **NIH NIH U42** · OREGON HEALTH & SCIENCE UNIVERSITY · 2021 · $499,999

## Abstract

PROJECT SUMMARY
The Oregon National Primate Research Center (ONPRC) Expanded SPF (ESPF) Rhesus Macaque Breeding
Colony is a highly specialized breeding colony that provides unique and essential macaques with an expanded
SPF definition for AIDS research. This colony is critical for AIDS-related opportunistic infection research and
vaccine vector development using opportunistic viral agents as vaccine vectors. In order to provide a sufficient
number of appropriate animals, the breeding colony must produce 30 surplus animals annually. Concurrently, it
is necessary to isolate lymphocryptovirus (LCV) free animals and re-derive LCV-free offspring from LCV
seroconverted females in the colony and recruit additional LCV-free infants from Center's convention SPF
colony. A critical shortage of appropriate ESPF social housing severely constrain both our efforts to increase
the size of the breeding colony to meet project demand and our endeavors to eliminate LCV from the colony.
The application proposes to complete modifications of the existing southwest outdoor sheltered housing
structure providing an additional four 500 sq. ft. social housing units. The proposed modifications would
expand the total number of outdoor ESPF breeding animals housed in social groups permitting increased
production, facilitate genetic management by providing smaller housing units that are more appropriate for
housing 7-10 females and a male and offspring, provide sufficient separation between individual housing units
to prevent transmission of agents between groups, and improve animal welfare through social housing.

## Key facts

- **NIH application ID:** 10360780
- **Project number:** 3U42OD023038-06S1
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** Michael K Axthelm
- **Activity code:** U42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $499,999
- **Award type:** 3
- **Project period:** 2016-08-01 → 2024-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10360780

## Citation

> US National Institutes of Health, RePORTER application 10360780, Phase 2 Enhancement of Outdoor Group Housing for U42 SPF 9 Rhesus Macaques (3U42OD023038-06S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10360780. Licensed CC0.

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