# Does getting older signal improved mood repair for people with early-onset mood disorder histories? A longitudinal study of outcomes and mechanisms across middle age

> **NIH NIH R01** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2021 · $163,824

## Abstract

Project Summary
We are requesting an administrative supplement to make up for the loss of subject enrollment into the study
during more than six months of state-mandated closure of our lab due to Covid-19 (while project staff
continued to receive salaries). We need to finish recruitment of the proposed sample in order to fulfill the aims
of the study and have the statistical power to test key hypotheses. The goals of this study remain as originally
proposed. We were to build on a unique sample of Ss, heterogeneous with respect to risk of depressive
disorder, who (in prior research studies) repeatedly reported during ages 18-35+ on their emotional well-being
and how they attenuate sadness/distress (mood repair); their autonomic nervous system (ANS) functioning
associated with affect processing was also assessed via peripheral measures. We propose to re-assess n=225
with histories of diagnosed depression and n=200 with no histories of depression once more, and thus extend
the data base up to age 59 years, covering middle-age. We will identify latent trajectories of trait mood repair
from ages 18 to 59 years and determine its correlates and the effects of personality, treatment exposure and
ANS physiologic functioning on class membership; will examine the ability to repair mood in the laboratory; we
will use a novel experimental procedure (the Cognitive Effort Discounting Paradigm or COG-ED), which
quantifies the subjective cost of cognitive effort (involved in cost-benefit computations to perform a task), to
examine the impact of affective load on effort-based decision making. We will test several clearly articulated
hypotheses about : i) the effects of depressive illness history and sex on positive maturational effects in mood
repair with age, ii) the predictive/moderating values of personality and treatment exposure on age-related
mood repair changes, iii) the relations of latent-class mood repair trajectories to sex and shifts in ANS
functioning over time; iv) the predictive value of latent-class mood repair trajectories for mood repair success
in the laboratory; v) ever-depressed and never-depressed group-related differences on the COG-ED, and vi)
the relations of COG-ED performance to mood repair trajectory membership and lab-based mood repair
performance via attention refocusing. Our study will fill several gaps in the literature on emotion regulation and
aging and represents the first step to assess the extent to which a neuro-economic approach to decision
making reflects a mechanism that may explain mood repair choices.

## Key facts

- **NIH application ID:** 10361803
- **Project number:** 3R01MH113214-04S1
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** MARIA KOVACS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $163,824
- **Award type:** 3
- **Project period:** 2017-07-01 → 2022-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10361803

## Citation

> US National Institutes of Health, RePORTER application 10361803, Does getting older signal improved mood repair for people with early-onset mood disorder histories? A longitudinal study of outcomes and mechanisms across middle age (3R01MH113214-04S1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10361803. Licensed CC0.

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