# Administrative Supplement to Regulators of retinal metabolism in healthy and degenerating retinas

> **NIH NIH R01** · UNIVERSITY OF FLORIDA · 2021 · $130,524

## Abstract

Abstract:
The retina hashigh metabolic activity,and retinal degenerations have been associated with
mitochondrial dysfunction, dysregulation of metabolism, and toxic oxidative damage. However,
little is known about how metabolism is maintained under normal conditions or is dysregulated
in degenerating retinas. AMPK (AMP-activated protein kinase)is a key regulator of metabolism
in highly metabolic tissues and is a candidate to regulate metabolism in photoreceptors, and its
role in retinal metabolism will be rigorously studied in this proposed project using both gain-of-
function and loss-of-function approaches. Peroxisome proliferator-activated receptor gamma
coactivator-alpha (PGC-1α) and beta (PGC-1β) are key regulators of mitochondrialbiogenesis.
Adenosine monophosphate dependent kinase (AMPK) is an important regulator of PGC-1
activity. Our goal in this study isto determine the rolesof AMPK and PGC-1activity in retinal
photoreceptors.

## Key facts

- **NIH application ID:** 10361928
- **Project number:** 3R01EY031720-01S1
- **Recipient organization:** UNIVERSITY OF FLORIDA
- **Principal Investigator:** John D Ash
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $130,524
- **Award type:** 3
- **Project period:** 2020-09-01 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10361928

## Citation

> US National Institutes of Health, RePORTER application 10361928, Administrative Supplement to Regulators of retinal metabolism in healthy and degenerating retinas (3R01EY031720-01S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10361928. Licensed CC0.

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