# Developing tools to study relationship between oxidative stress in T cell dysfunction

> **NIH NIH R03** · WASHINGTON UNIVERSITY · 2022 · $78,750

## Abstract

Abstract
 In response to chronic viral infection or in tumor microenvironment, antigen(Ag)-specific CD8 T cells
undergo alternative activation processes, called exhaustion. Exhausted CD8 T cells lose their proliferation and
effector gene expression, thus allowing viral infection or tumor growth to persist despite the initial expansion of
antigen-specific clones. Although the precise mechanism driving T cell exhaustion is unknown, literature
suggests that exposure of T cells to excessive oxidative stress contribution to the establishment of exhaustion.
In this small grant, we propose to generate genetically modified mice that facilitate visualization of cells that are
exposed to oxidative stress and use the tools for future studies for T cell exhaustion.

## Key facts

- **NIH application ID:** 10362128
- **Project number:** 1R03AI166801-01
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** Takeshi Egawa
- **Activity code:** R03 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $78,750
- **Award type:** 1
- **Project period:** 2021-11-01 → 2023-10-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10362128

## Citation

> US National Institutes of Health, RePORTER application 10362128, Developing tools to study relationship between oxidative stress in T cell dysfunction (1R03AI166801-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10362128. Licensed CC0.

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