# Establishment of a SPF Rhesus Macaque Colony

> **NIH NIH U42** · TEXAS BIOMEDICAL RESEARCH INSTITUTE · 2021 · $499,999

## Abstract

U42 AR Supplement: SNPRC Proposal to expand U42 rhesus monkey holding and Production.
Abstract
The Southwest National Primate Research Center (SNPRC) has developed an SPF Indian-derived (ID) rhesus
colony, supported by the NIH SPF rhesus breeding program (U42 OD010442). HIV/AIDS research at the center
strongly supports both internal and external scientists whose work investigates critical topics including, but not
limited to, Mtb/HIV coinfection, development of nanoparticle vaccines against SIV/HIV, HIV/SHIV infection in
newborn rhesus monkeys, role of miRNA’s in gastrointestinal dysfunction in the HIV/SIV rhesus model, the
investigation of CNS myeloid cells as chronic reservoirs in SIV-infected primates, and the development of host-
directed therapies against SIV/HIV and Mtb/HIV infection. There has been a critical shortage of these primates
for research for over a decade. The sudden usage of rhesus macaques for COVID-19 research—necessitated
by the pandemic—has created further strain on the availability of this primate model for HIV/AIDS research [NOT-
OD-20-173. September 11, 2020 ‘Notice of Limited Availability of Research Nonhuman Primates’]. In order to
meet urgent needs for recent COVID-19 research, SNPRC rhesus macaques, over the past year, have been
mostly directed to these studies as required by Operation Warp Speed and directives put forth from the NIH.
This has severely impacted our ability to maintain research primates for our HIV/AIDS investigators under the
U42 funding. There is an acute, urgent need to increase production of these U42 SPF Indian-derived primates.
This application proposes to increase holding and breeding space at the SNPRC to support expansion of this
colony.

## Key facts

- **NIH application ID:** 10362396
- **Project number:** 3U42OD010442-20S1
- **Recipient organization:** TEXAS BIOMEDICAL RESEARCH INSTITUTE
- **Principal Investigator:** Deepak Kaushal
- **Activity code:** U42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $499,999
- **Award type:** 3
- **Project period:** 2021-05-15 → 2022-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10362396

## Citation

> US National Institutes of Health, RePORTER application 10362396, Establishment of a SPF Rhesus Macaque Colony (3U42OD010442-20S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10362396. Licensed CC0.

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