# Molecules and Pathways at the Coccidioides Host-Pathogen Interface

> **NIH NIH U19** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2022 · $1,736,000

## Abstract

Summary (Overall, Sil and Dandekar)
The overarching theme of the proposed Coccidioides Collaborative Research Center (CCRC) is to identify
molecules and pathways at the Coccidioides host-pathogen interface. Our long-term goal is to analyze the dialog
between fungus and the host immune system in the context of models (macrophages and mice) and in the
context of chronic and disseminated infections (in humans). Our expertise with basic mycology will facilitate our
determination of Coccidioides factors that are critical for causing disease. Our rich source of clinical samples
from the endemic region of California and our access to technological innovation will facilitate our ability to identify
molecules, cells, metabolites, and pathways that correlate with a patient context that is permissive or restrictive
for dissemination. Our expertise with data analysis will promote the integration of our molecular findings to
generate an understanding of host response pathways that are correlated with disease state and clinical outcome.
Additionally, we will evaluate the diagnostic potential of Coccidioides antigens and host biomarkers, thereby
closing existing gaps in the diagnosis of coccidioidomycosis. At the same time, we will make key basic
discoveries in microbial biology and host response, driving the field of fungal pathogenesis and medical mycology
forward. Finally, by integrating the data from Projects and Cores, we hope to identify new molecular targets for
anti-fungal development as well as host pathways that could be targeted by novel or existing biologics to tip the
immune response in favor of the host.

## Key facts

- **NIH application ID:** 10364963
- **Project number:** 1U19AI166798-01
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Satya Dandekar
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $1,736,000
- **Award type:** 1
- **Project period:** 2022-01-01 → 2026-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10364963

## Citation

> US National Institutes of Health, RePORTER application 10364963, Molecules and Pathways at the Coccidioides Host-Pathogen Interface (1U19AI166798-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10364963. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*