# The AnVIL Data Ecosystem DACReS Supplement

> **NIH NIH U24** · BROAD INSTITUTE, INC. · 2021 · $112,763

## Abstract

Project Summary
The goals of this administrative supplement are to advance implementation science research related to, and build technical
capacities in ethical access to human genomic data. Genomic and associated phenotypic data fuel the engines of scientific
discovery in the precision medicine era, but data are being generated at a pace and in volumes that overwhelm the ability
of many institutions to enable their secure and efficient access. Existing strategies for governing access rely on institution-
specific procedures guiding data access committee (DAC) review and manual verification of data use restrictions. Both
strategies are incompatible with the shift towards cloud-based research environments exemplified by the AnVIL Data
Ecosystem and insufficient to meet high demand for dynamic, real-time adjudication of access requests. The parent grant
to this supplement developed the Data Use Ontology System (DUOS) to innovatively solve this problem. DUOS is a
service which provides software-enabled workflows and policies for DACs, including semi-automating two steps in the
existing DAC workflow using global standards. In the course of our preliminary evaluations, however, we recognized that
DACs affiliated with publicly funded genomic data repositories in the U.S. and abroad will require additional technical
and adaptive capacities to facilitate successful implementation of DUOS and future semi-automated workflow solutions
similar to it. The criticalness of secure, compliant, and efficient data access management to the speed of science, and lack
of standard procedures and policies to do so, creates clear opportunities to (i) study relevant factors that influence whether
and how DACs implement workflow solutions that improve consistency and efficiency of data access review and to (ii)
develop procedural standards for DACs using an international, consensus deliberation approach. To accomplish these
aims, the AnVIL team will collaborate with three co-leads of the Data Access Committee Review Standards Working
Group (DACReS WG), whose members represent DACs from the NIH and the largest publicly funded genomic data
repositories in the world. Taken together, the AnVIL and DACReS create a uniquely interdisciplinary team whose
collaboration will generate a novel evidence basis to inform how future DAC policies account for machine-assisted
review of access requests to valuable genomic data resources and that will develop and validate procedural standards upon
which current, new and prospective DACs can refer.

## Key facts

- **NIH application ID:** 10365770
- **Project number:** 3U24HG010262-04S2
- **Recipient organization:** BROAD INSTITUTE, INC.
- **Principal Investigator:** Robert J Carroll
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $112,763
- **Award type:** 3
- **Project period:** 2018-09-19 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10365770

## Citation

> US National Institutes of Health, RePORTER application 10365770, The AnVIL Data Ecosystem DACReS Supplement (3U24HG010262-04S2). Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/grant/nih/10365770. Licensed CC0.

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