# RADx-UP CDCC SAY YES COVID Test Study

> **NIH NIH U24** · DUKE UNIVERSITY · 2021 · $7,653,833

## Abstract

Over 4 million people have been infected with the SARS-CoV-2 virus and more than 460,000 have died. Novel
mitigation strategies and community level public health interventions are critical to stop the spread of this virus.
The goal of frequent home testing is to identify SARS-CoV-2 index cases early, trigger isolation and
quarantining precautions, and ultimately decrease community transmission. We will evaluate a public health
intervention combining frequent at-home testing with broad community engagement strategies, to reduce
SARS-CoV-2 virus community transmission and conduct a study in a cohort of the population to understand
the human behavior factors affecting viral testing. This approach will allow us to answer questions regarding
community transmission for the SARS-CoV-2 pandemic as well as additional questions relevant for
implementation of public health interventions in future pandemics. We will partner with the CDC to evaluate
community dissemination of 2 million rapid tests in a public health intervention of rapid, twice weekly at home
testing in up to 3 communities 1) with high prevalence of disease 2) that have reliable publicly available
outcome data and 3) that overlap with current RADx-UP sites to leverage the robust infrastructure of the CDCC
and support community engagement through the testing projects. To evaluate whether frequent rapid at-home
testing strategy decreases community transmission of and morbidity from SARS-CoV-2 over a 5-week period,
our primary outcomes include measures of community transmission (hospital capacity/health care utilization,
composite measure of community transmission, wastewater surveillance), and morbidity (hospitalizations,
covid-like illness). Our secondary outcomes include (community mobility, PCR turn-around time, ICU
admissions, contact tracing episodes, and percent test positivity). In addition, we will conduct a substudy to
assess behavioral determinants of testing (social interaction, health behaviors, healthcare utilization,
prevention knowledge and vaccine attitudes) using a smart phone application with consenting participants in
the public health intervention.

## Key facts

- **NIH application ID:** 10366485
- **Project number:** 3U24MD016258-01S1
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** Michael Cohen-Wolkowiez
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $7,653,833
- **Award type:** 3
- **Project period:** 2020-09-27 → 2023-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10366485

## Citation

> US National Institutes of Health, RePORTER application 10366485, RADx-UP CDCC SAY YES COVID Test Study (3U24MD016258-01S1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10366485. Licensed CC0.

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