# NAD-dependent Signaling and Pulmonary Vascular Remodeling in PAH

> **NIH NIH R01** · INDIANA UNIVERSITY INDIANAPOLIS · 2022 · $719,485

## Abstract

ABSTRACT
Pulmonary arterial hypertension (PAH), a rare, debilitating and fatal disease for which there is currently no
available cure. There is compelling evidence that NAD-dependent signaling via NAMPT is a novel and
therapeutic target for PAH. To facilitate the translation of current in vivo and in vitro observations on the
role of NAMPT dependent signaling in PAH pathobiology, this proposal will explore the hypothesis that the
NAMPT/NAD signaling axis regulates physiologic, cellular and molecular pathways in PAH that result in
pulmonary vascular remodeling. SA1 seeks to define the role of pulmonary artery endothelial cell NAMPT in
the regulation on metabolic reprograming associated with the PH response. SA2 define the role of NAMPT in
regulating mitochondrial dynamics in pulmonary artery endothelial cells. SA3 will seek discover and validate
biochemical and genetic NAMPT-centric biomarkers of PAH susceptibility and prognosis.

## Key facts

- **NIH application ID:** 10366989
- **Project number:** 1R01HL158108-01A1
- **Recipient organization:** INDIANA UNIVERSITY INDIANAPOLIS
- **Principal Investigator:** Roberto F. Machado
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $719,485
- **Award type:** 1
- **Project period:** 2022-03-01 → 2026-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10366989

## Citation

> US National Institutes of Health, RePORTER application 10366989, NAD-dependent Signaling and Pulmonary Vascular Remodeling in PAH (1R01HL158108-01A1). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10366989. Licensed CC0.

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