# Biosignatures of Executive Dysfunction in Down Syndrome

> **NIH NIH R01** · COLORADO STATE UNIVERSITY · 2021 · $875,785

## Abstract

Abstract
This Competing Revision will expand the scope of R01HD099150-0, a five-year project that involves extensive
data collection on cognition and executive function in young children with Down syndrome (DS). The focus of
R01HD099150-0 is outcome measure validation for future treatment work in DS, and the proposed revision will
provide funds to support the collection and analysis of blood samples concurrently with cognitive assessment.
Supplementing the parent project data with blood sample collection and multi-omics analyses will leverage the
wealth of cognitive phenotyping data on this cohort of young children with DS, and make it possible to
preliminarily test a model of executive dysfunction in DS that can inform the development of novel treatments.
Blood samples will be collected from 60 children who enroll in Wave 1 of the parent R01 project during project
years 3 and 4. All children will have chronological ages between 2.5-7.99 years. Proposed analyses will seek to
identify multi-omics signatures of executive dysfunction in the transcriptome, proteome, metabolome, and
immune profile. The ultimate goal of this Competing Revision will be to identify endotype features associated
with variable executive dysfunction in DS. This integrated biobehavioral examination of executive dysfunction
in DS is novel, and has the potential to transform treatment science for young children with DS and promote
healthy developmental outcomes and well-being in this population.

## Key facts

- **NIH application ID:** 10367151
- **Project number:** 3R01HD099150-03S1
- **Recipient organization:** COLORADO STATE UNIVERSITY
- **Principal Investigator:** DEBORAH J FIDLER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $875,785
- **Award type:** 3
- **Project period:** 2019-09-13 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10367151

## Citation

> US National Institutes of Health, RePORTER application 10367151, Biosignatures of Executive Dysfunction in Down Syndrome (3R01HD099150-03S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10367151. Licensed CC0.

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