# Age-specific differentiation of multipotent progenitors

> **NIH NIH R03** · BOSTON CHILDREN'S HOSPITAL · 2022 · $132,750

## Abstract

PROJECT SUMMARY/ABSTRACT
The foundation of this project is based on the clinical observation that adults and children are affected by
different blood disorders, many of which show typical age biases. Accumulating evidence supports the notion
that the scripted changes that occur normally in the hematopoietic system during development and aging
create transient, age-specific hematopoietic substrates in which these diseases develop. The blood forming
system undergoes a controlled maturation process wherein the prioritized lineage outputs, mechanisms of
lineage restriction, and rates of hematopoietic stem cell (HSC) self-renewal change from early development
through maturation of the organism. Postnatally, as the hematopoietic system ages, these changes continue
with a progressive myeloid bias and further diminishment of HSC self-renewal. These temporal changes in the
mechanisms of blood formation appear to be regulated both intrinsically and extrinsically, as both the anatomic
location and cellular composition of the hematopoietic microenvironment change with time in concert with the
function of HSCs. Our prior K08-supported research has identified a novel potential mechanism of epigenetic
control of the transition from the transient, juvenile state of hematopoiesis to mature adult hematopoiesis.
Here, we will investigate molecular mechanisms regulating the shifting lineage biases that occurs during
hematopoietic maturation.

## Key facts

- **NIH application ID:** 10368284
- **Project number:** 1R03DK126729-01A1
- **Recipient organization:** BOSTON CHILDREN'S HOSPITAL
- **Principal Investigator:** Robert Grant Rowe
- **Activity code:** R03 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $132,750
- **Award type:** 1
- **Project period:** 2022-01-07 → 2023-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10368284

## Citation

> US National Institutes of Health, RePORTER application 10368284, Age-specific differentiation of multipotent progenitors (1R03DK126729-01A1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10368284. Licensed CC0.

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