# IMPAACT RELATED PROTOCOLS FOR THE RESEARCH ON TREATMENT, PREVENTION, DIAGNOSIS AND EPIDEMIOLOGY OF HIV INFECTIONS

> **NIH NIH N01** · WESTAT, INC. · 2021 · $2,486,704

## Abstract

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) 
provides clinical trial sites to the International Maternal Pediatric Adolescent AIDS Clinical 
Trials Group (IMPAACT). The IMPAACT network and its leadership group oversee the creation of all 
their studies, protocols, and clinical trials. The IMPAACT Network is a cooperative group of 
institutions, investigators, and other collaborators mainly focused on evaluating potential 
therapies for HIV infection and its related symptoms and co-infections in infants, children, 
adolescents and pregnant women. This includes clinical trials of HIV/AIDS interventions for the 
prevention of mother to child transmission.

The IMPAACT Network goal is to conduct high quality clinical trials and/or protocols that will 
advance the prevention and treatment of HIV and its complications for infants, children, 
adolescents, and pregnant/ postpartum women globally. The IMPAACT research agenda in this task 
order includes four scientific specific aims, which reflect the key areas of work. Those areas are 
HIV Treatment, HIV Prevention, HIV Cure, and HIV Complications. For each area, a Scientific 
Committee composed of experts in the specific field, site investigators, community representatives, 
and representatives of the central network resources, continually reassesses the research 
priorities in light of emerging science as well as new ideas and opportunities; it seeks 
collaboration with other trials networks and research entities; oversees the formulation and review 
of study concept plans based on the scientific priorities; and monitors the development and 
implementation of approved network studies in the specific research area.

In  1990  the  NICHD  began  collaborating  with  the  Pediatric  AIDS  Clinical  Trials  Group  
(PACTG)  to expand clinical  trial  availability  at  NICHD  clinical  trial  centers/sites.  This  
collaboration  made  possible to   conduct   clinical  trials  by  the  IMPAACT  Network  to    
further  evaluate  antiretroviral  therapeutic agents,  other    therapies    targeted    at    
opportunistic    infections,    and    interventions    to    prevent perinatal   HIV transmission. 
 In  recent  years,  the  collaboration  is  expanding  to  evaluate  potential  HIV cure  
approaches  and vaccines.

The purpose of this task order is to recruit, follow and complete the IMPAACT Related protocols 
listed below. The integration of the results of these 2 protocols, which will be presented in a 
final report, will provide data to advance the prevention, treatment and remission of HIV, its most 
common complications and related infectious diseases in maternal, adolescent and pediatric 
populations.

For the last 35 years NICHD/NIAID as part of the scientific community have been conducting intense 
HIV research. During this time, it became clear that to be successful in the attempt to curve the 
HIV infection rates of the epidemic, and appropriat...

## Key facts

- **NIH application ID:** 10369859
- **Project number:** 275201800001I-0-759402100001-1
- **Recipient organization:** WESTAT, INC.
- **Principal Investigator:** BARBARA DRIVER
- **Activity code:** N01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $2,486,704
- **Award type:** —
- **Project period:** 2021-03-01 → 2026-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10369859

## Citation

> US National Institutes of Health, RePORTER application 10369859, IMPAACT RELATED PROTOCOLS FOR THE RESEARCH ON TREATMENT, PREVENTION, DIAGNOSIS AND EPIDEMIOLOGY OF HIV INFECTIONS (275201800001I-0-759402100001-1). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10369859. Licensed CC0.

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