# Interferon-modulated vaccines against HIV

> **NIH NIH DP2** · NORTHWESTERN UNIVERSITY · 2021 · $222,322

## Abstract

PROJECT SUMMARY
We have elucidated a strategy to improve viral vaccines by combining IFN-I receptor antibodies with the vaccine.
Our data show that this approach improves the efficacy of multiple viral vaccines, including the clinically approved
yellow fever vaccine and experimental HIV vaccines in mice. Such data provide impetus for testing whether IFN-
modulation can also improve the efficacy of HIV vaccines in primates and humanized mice challenged
intravenously with HIV.
These data are potentially translatable to humans, since there is a similar antibody that has undergone extensive
clinical testing in humans to block IFN-I (Anifrolumab).

## Key facts

- **NIH application ID:** 10370077
- **Project number:** 3DP2DA051912-01S1
- **Recipient organization:** NORTHWESTERN UNIVERSITY
- **Principal Investigator:** Pablo Penaloza-MacMaster
- **Activity code:** DP2 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $222,322
- **Award type:** 3
- **Project period:** 2020-07-01 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10370077

## Citation

> US National Institutes of Health, RePORTER application 10370077, Interferon-modulated vaccines against HIV (3DP2DA051912-01S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10370077. Licensed CC0.

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