# Improving Psychological Outcomes for Acute Respiratory Failure Survivors using a Self-Management Intervention

> **NIH NIH K23** · JOHNS HOPKINS UNIVERSITY · 2022 · $157,985

## Abstract

An increasing number of adults in the U.S. develop acute respiratory failure (ARF) requiring mechanical
ventilation in an intensive care unit (ICU). To improve patient outcomes, evidence-based guidelines
recommend titrating sedatives to allow for patient wakefulness while in the ICU. However, among awake ARF
patients, anxiety can be a common and long-lasting problem. Outside of the ICU setting, self-management
interventions are established, evidence-based, first-line treatments for patients with anxiety. However, there is
limited evidence about the feasibility and benefit of self-management interventions for ARF patients during
hospitalization. Hence, this K23 proposal seeks to: 1) conduct a qualitative study in hospitalized patients to
refine an existing Self-Management in Acute Respiratory Failure (SMARF) intervention (Aim 1), and 2) conduct
a pilot randomized controlled trial (RCT) of the refined SMARF intervention vs. usual care in the ICU and wards
to establish its feasibility, acceptability (primary outcome; Aim 2a), and potential efficacy in reducing anxiety
symptoms and associated outcomes at hospital discharge (Aim 2b) and at 3-month follow-up (secondary
outcomes; Aim 3).
 Megan Hosey, PhD, a practicing clinical psychologist and Assistant Professor at the Johns Hopkins
School of Medicine, has a long-term career goal of becoming an independent, patient-oriented researcher in
acute respiratory failure, examining early interventions to reduce psychological symptoms and improve long-
term functional outcomes. Through this K23 award, Dr. Hosey will achieve the following career goals: 1) gain
expertise in qualitative research via didactic coursework and mentored practical experience, 2) deepen
knowledge and experience in patient-oriented research by completing a Master of Health Science (MHS)
degree in Clinical Investigation and conducting a pilot RCT, and 3) gain mentored experience with scientific
publication and grant writing. This award will result in preliminary data and skills that will lay the foundation for
a successful future R-level grant and pathway towards independent investigator status. This award will build
upon Dr. Hosey’s extensive clinical expertise in self-management interventions for ARF patients and her
research background in the psychosocial aspects of recovery from ARF via providing tailored didactic training
and mentored research experience with a world-class team, all occurring in a resource-rich academic
environment.

## Key facts

- **NIH application ID:** 10370615
- **Project number:** 1K23HL155735-01A1
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** Megan Hosey
- **Activity code:** K23 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $157,985
- **Award type:** 1
- **Project period:** 2022-02-01 → 2027-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10370615

## Citation

> US National Institutes of Health, RePORTER application 10370615, Improving Psychological Outcomes for Acute Respiratory Failure Survivors using a Self-Management Intervention (1K23HL155735-01A1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10370615. Licensed CC0.

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