# Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer's disease

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2022 · $6,679,538

## Abstract

Abstract
By 2060, the CDC projects that the Latino population will experience the largest increase in Alzheimer’s
disease and related dementia (ADRD) cases of all US ethnic/racial groups. The main explanation for high
Latino ADRD is attributed largely to early and excess cardiovascular disease (CVD) morbidity contributing
to disparately high ADRD. CVD risk factors emerge early in midlife among Latinos, thereby increasing
exposures to exquisitely sensitive and highly vascularized brain tissue. Yet, to-date there has not been any
study of Latinos with sufficiently deep CVD phenotyping and genotyping to adequately address this
significant public health question. This scientific knowledge gap is a significant impediment to the field and
public health given rapid Latino population growth projections, particularly for older adults. The Study of
Latinos-Investigation of Neurocognitive Aging-Alzheimer’s Disease (SOL-INCA-AD) will augment the
ongoing large, representative and unique cohort with 10-years of advanced biomarkers of Alzheimer's
disease to understand cognitive aging and impairment amongst diverse Latinos. Together with 10-years of
cognitive measures, MRI, deep CVD phenotyping, genomics and rich sociocultural data, SOL-INCA-AD is a
high priority study that will fill major scientific knowledge gaps that form barriers to progress for Latino
ADRD research.

## Key facts

- **NIH application ID:** 10370841
- **Project number:** 1R01AG075758-01
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** Charles DeCarli
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $6,679,538
- **Award type:** 1
- **Project period:** 2022-05-15 → 2027-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10370841

## Citation

> US National Institutes of Health, RePORTER application 10370841, Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer's disease (1R01AG075758-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10370841. Licensed CC0.

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