# Role of SIRT6 in the pancreatic beta cell aging

> **NIH NIH R21** · INDIANA UNIVERSITY INDIANAPOLIS · 2022 · $237,750

## Abstract

Project Summary
 During aging, pancreatic beta cells undergo a decline in insulin secretion capacity, and this
contributes to nearly 3-fold high diabetes prevalence in people aged over 65 years compared to the
general population. Sirtuin 6 (SIRT6), a histone deacetylase, has been suggested to be a longevity factor.
In the preliminary study, we have demonstrated that SIRT6 is required to maintain normal beta cell
function and SIRT6 is downregulated in the beta cells during aging. Therefore, we hypothesize that SIRT6
plays an important role in the protection of pancreatic beta cells against aging-associated cellular
damage. In this application, we will investigate the SIRT6 function and mechanism in the regulation of
pancreatic beta cell aging. It is our expectation that the findings from this project will advance our
understanding of the fundamental process of the aging of pancreatic beta cells and provide potential
novel targets for the development of prevention and treatment of the age-related diabetes.

## Key facts

- **NIH application ID:** 10371337
- **Project number:** 1R21AG072288-01A1
- **Recipient organization:** INDIANA UNIVERSITY INDIANAPOLIS
- **Principal Investigator:** X. Charlie Dong
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $237,750
- **Award type:** 1
- **Project period:** 2022-06-15 → 2024-02-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10371337

## Citation

> US National Institutes of Health, RePORTER application 10371337, Role of SIRT6 in the pancreatic beta cell aging (1R21AG072288-01A1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10371337. Licensed CC0.

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