# Spatial patterning in interglomerular inhibitory circuits

> **NIH NIH F32** · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2021 · $18,722

## Abstract

Abstract
The olfactory bulb is an excellent model system for the study of sensory neurophysiology and neural
information coding. Many lines of evidence indirectly suggest that spatial patterning of activity in the olfactory
bulb is important for encoding olfactory information, but the relationship between the spatial patterns of activity
in the bulb and olfactory stimulus space remain to be fully elucidated. Lateral inhibition in sensory systems is
related to the stimulus space of the sensory modality. In the glomerular layer of the olfactory bulb, lateral
inhibitory interactions between glomeruli are primarily mediated by short axon cells. This proposal expands on
previous work demonstrating that interglomerular inhibition is sparse and selective to directly test possible
mechanisms for this specificity. Two hypotheses relating to specificity of odor evoked inhibition are examined
through optical recordings of activity from the output neurons of the olfactory bulb, mitral and tufted cells, and
from short axon cells. This project will characterize the functional and spatial properties of interglomerular
inhibition by stimulating olfactory activity with odors and optogenetic techniques. The results of these
experiments will yield new insight into the role of interglomerular inhibition and the short axon cell network.

## Key facts

- **NIH application ID:** 10371469
- **Project number:** 3F32DC016536-03S1
- **Recipient organization:** UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
- **Principal Investigator:** Isaac Youngstrom
- **Activity code:** F32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $18,722
- **Award type:** 3
- **Project period:** 2018-06-01 → 2021-09-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10371469

## Citation

> US National Institutes of Health, RePORTER application 10371469, Spatial patterning in interglomerular inhibitory circuits (3F32DC016536-03S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10371469. Licensed CC0.

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