# Mitochondrial Biochemistry: From Mechanisms to Disease

> **NIH NIH R35** · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2022 · $381,250

## Abstract

Project Summary/Abstract
Mitochondria are the major source of cellular energy and are also one of the major sites of defects leading to
age-related disorders. In spite of the obvious importance, roughly 1/3 of the proteins found there have no
know function. One major goal of the Rutter laboratory is to define the functions of a subset of these proteins,
particularly those that are highly evolutionarily conserved across eukaryotic species. We have begun this
process and have defined the molecular functions of ten mitochondrial protein families. These have included
important factors for OXPHOS complex assembly, mitochondrial quality control, metabolic regulation and
others. These discoveries have enabled our laboratory and many others to develop new understanding of
normal human physiology and disease pathophysiology, including the discovery of two new human disease
genes. The proposed future activities are a combination of continuing our efforts to define the functions of
previously unstudied mitochondrial proteins and leveraging our previous discoveries toward a better
understanding of mitochondrial biology and its physiological manifestations.

## Key facts

- **NIH application ID:** 10372005
- **Project number:** 5R35GM131854-04
- **Recipient organization:** UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
- **Principal Investigator:** Jared P Rutter
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $381,250
- **Award type:** 5
- **Project period:** 2019-04-01 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10372005

## Citation

> US National Institutes of Health, RePORTER application 10372005, Mitochondrial Biochemistry: From Mechanisms to Disease (5R35GM131854-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10372005. Licensed CC0.

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