# COBRE for Skeletal Health & Repair

> **NIH NIH P30** · RHODE ISLAND HOSPITAL · 2021 · $201,416

## Abstract

Overall
7. Project Summary/Abstract
The long-term goal of the Center of Biomedical Research Excellence (COBRE) for Skeletal Health and Repair
is to develop a multi-disciplinary translational research center focusing on discovering mechanisms of cartilage
joint diseases and developing prevention and treatment strategies. Since the start of the COBRE eight years
ago, seven full project investigators have received R01 or R01-equivalent federal grants and “graduated” from
the COBRE training program, and published more than 240 peer-reviewed articles including landmark
discoveries in Nature, Molecular Cell, and PNAS. All twenty target junior investigators have received exramural
funding as Principal Investigator, and new state-of-the-art laboratories and core facilities have been built in
bioengineering, imaging, molecular biology and nanomedicine. The main objective of the Phase III COBRE is
to strengthen and transition the COBRE research infrastructure into a competitive, independent, and self-
sustaining academic center of excellence-Brown Center of Musculoskeletal and Motion Sciences (BCMMS) in
five years. To achieve this main objective, four specific aims are proposed as follows. Aim 1, Administrative
Core provides strong leadership in translational research, evaluates the performance of technical Core
Resources and Facilities, guides mentoring efforts in the Pilot Projects Program, and implements the COBRE
transitioning plan; Aim 2, Bioengineering Core enhances an interactive research environment and provides the
unique resources of biomechanical testing at the cell, tissue, and organ levels; Aim 3, Imaging, Molecular
Biology, and Nanomedicine Core enhances translational research from bench to bedside, provides critical
expertise and equipment in small animal live imaging analysis, and facilitates development of novel
nanomaterial delivery vehicles for diagnostics and therapeutics; and Aim 4, Pilot Projects Program mentors a
new generation of researchers in multiple disciplines of musculoskeletal research including clinicians,
biologists, and engineers, facilitates research collaborations, and sustains the strong research environment
developed in the first two phases of COBRE. Our vision is, by sustaining and transitioning the established high-
caliber research infrastructure, we will enable clinicians working side-by-side with basic research scientists,
junior investigators with senior investigators, and biologists with bioengineers for a long term into the future.

## Key facts

- **NIH application ID:** 10372256
- **Project number:** 3P30GM122732-04S1
- **Recipient organization:** RHODE ISLAND HOSPITAL
- **Principal Investigator:** QIAN CHEN
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $201,416
- **Award type:** 3
- **Project period:** 2017-09-01 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10372256

## Citation

> US National Institutes of Health, RePORTER application 10372256, COBRE for Skeletal Health & Repair (3P30GM122732-04S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10372256. Licensed CC0.

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