# Posttraumatic Stress Disorder Intervention for People with Severe Mental Illness in Low- and Middle-Income Country Primary Care Settings

> **NIH NIH K23** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2021 · $89,984

## Abstract

PROJECT SUMMARY
Background: Low- and middle-income countries (LMICs) have very few mental health professionals. Given the chronic
nature of mental disorders, primary care clinics may be best positioned to address mental health in LMICs. However,
little is known about factors that influence real-world service delivery, access, quality, and sustainability of mental health
interventions in LMIC primary care. Researching whether and how mental health services can be feasibly and effectively
delivered in LMIC primary care is a NIMH priority and a grand challenge in global mental health. Severe mental illness
(SMI) is the most common form of mental illness seen in primary care clinics in LMICs, and is a top contributor to the
burden of disease. People with SMI are at high risk of developing posttraumatic stress disorder (PTSD), which is
associated with more severe psychiatric symptoms, functional impairment, and worse treatment outcomes. Specific
aims: The current study proposes to develop and assess the feasibility, effectiveness and implementation of a
psychotherapy intervention to treat PTSD in patients with SMI in primary care clinics in rural Ethiopia. Aim 1: Semi-
structured qualitative interviews were conducted with patients, caregivers, providers and community members (n=48) to
identify clinically and culturally relevant characteristics of the population and characterize barriers and facilitators to
intervention adoption, implementation and sustainability. Results were used to assess the fit and development of the
intervention; Aim 2: To conduct a mixed methods feasibility trial to refine the intervention and explore initial treatment
effects (n=40 patients); Aim 3: To conduct a mixed methods multi-stakeholder process evaluation to assess intervention
implementation as measured by the RE-AIM implementation framework (n=40, 12 providers). Candidate: This
Mentored Patient-Oriented Research Career Development Award (K23) builds upon the candidate's experience in
trauma-focused global mental health research in low-income countries. The candidate's long-term career goal is to be an
independent investigator of evidence-based interventions for PTSD and SMI in LMICs. Training objectives: The K23
provides training and mentorship in (1) the course, prevalence and treatment of comorbid PTSD and SMI; (2) health
services research, including methods to evaluate how healthcare is delivered and accessed in Ethiopian primary care,
and factors that might influence delivery of a psychosocial intervention for PTSD; and (3) implementation science
methods to decrease “science-to-service” gaps in providing mental health care in LMIC primary care, including hybrid
effectiveness-implementation trials. Training activities. Training will be achieved through mentorship by experts (Drs.
Cindy Yee-Bradbury, David Henderson, Abebaw Fekadu, Charlotte Hanlon, and Kim Mueser), field-based experience in
Ethiopia, formal coursework, and seminars, trainings, and conference and wor...

## Key facts

- **NIH application ID:** 10372448
- **Project number:** 3K23MH110601-06S1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** Lauren Christina Ng
- **Activity code:** K23 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $89,984
- **Award type:** 3
- **Project period:** 2016-09-01 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10372448

## Citation

> US National Institutes of Health, RePORTER application 10372448, Posttraumatic Stress Disorder Intervention for People with Severe Mental Illness in Low- and Middle-Income Country Primary Care Settings (3K23MH110601-06S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10372448. Licensed CC0.

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