# UF PASS: Regulation of exercise transducers: supplement for diverse students

> **NIH NIH U01** · UNIVERSITY OF FLORIDA · 2021 · $34,591

## Abstract

Abstract: The purpose of this Research Supplement is to Promote Diversity in Health-Related Research
through support of the career development training for Bryan Alava, a current PhD student at the
University of Florida. This administrative supplement will facilitate career development for the candidate
and as well as contribute to the mission of the parent project - to discover novel exercise induced health
related outcomes. The parent award is part of the MoTrPAC consortium that combines well defined
exercise interventions with multi-omics analysis to develop a map of molecular transducers that link
exercise to systemic health. To date, the consortium is analyzing the multi-omics data across 17 different
tissues collected following a defined treadmill exercise paradigm as part of the preclinical studies.
The primary objectives of Mr. Alava’s proposed research are two-fold: First to use a defined Alzheimer’s
Disease (AD) mouse model to characterize changes in skeletal muscle function and blood markers of
inflammation and metabolism. Second, once characterized we will use this model to test a treadmill
training protocol, based on the protocol used for MoTrPAC, for efficacy in delaying the progression of
AD. We will also be in a position to access the larger multiomics data available from MoTrPAC to expand
potential molecular targets of exercise and AD pathology. Dr. Esser, the PI of the U01, will be one of two
primary mentors for Mr. Alava. Dr. Jose Abisambra is the other co-mentor as his lab provides the AD
mouse model and expertise in the analysis of brain pathologies. Drs. Esser and Abisambra are already
official co-mentors for Bryan Alava within the Ph.D. program in the Department of Physiology and
Functional Genomics within the College of Medicine at the University of Florida. We have outlined a
series of didactic and experiential training activities that will equip Mr. Alava with the necessary skills to
progress as an independent scientist and to fulfill the NIH mission to advance the careers of a diverse
population of scientists.

## Key facts

- **NIH application ID:** 10372539
- **Project number:** 3U01AG055137-05S2
- **Recipient organization:** UNIVERSITY OF FLORIDA
- **Principal Investigator:** Karyn A Esser
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $34,591
- **Award type:** 3
- **Project period:** 2016-12-15 → 2022-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10372539

## Citation

> US National Institutes of Health, RePORTER application 10372539, UF PASS: Regulation of exercise transducers: supplement for diverse students (3U01AG055137-05S2). Retrieved via AI Analytics 2026-09-03 from https://api.ai-analytics.org/grant/nih/10372539. Licensed CC0.

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