# Integrators of Metastatic Potential

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2021 · $98,453

## Abstract

Metastases cause major morbidities and nearly all of deaths in patients with breast cancer and other solid
tumors. Our preliminary studies point to an intracellular signaling molecule, GIV, as a central determinant of
metastatic potential of breast cancer cells. GIV integrates signals from multiple biochemical and mechanical
inputs, placing this molecule as a central hub for key processes driving metastasis. In the parental RO1, we
propose to investigate functions of GIV in breast cancer metastasis through a combination of cell-based
assays and mouse models. We expect these studies to establish GIV as a potential predictive biomarker and
therapeutic target for breast cancer. The research re-entry supplement will support the applicant and her return
to a research career. The applicant will participate in all aspects of the proposed research, including planning
experiments, analyzing data, and publishing manuscripts. She will learn new experimental methods focused on
multi-scale, quantitative microscopy to complement her existing skills in cell and molecular biology. The
supplement will enable the applicant to successfully transition back into a successful career in biomedical
research.

## Key facts

- **NIH application ID:** 10372682
- **Project number:** 3R01CA238042-03S1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** Pradipta Ghosh
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $98,453
- **Award type:** 3
- **Project period:** 2021-06-01 → 2024-02-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10372682

## Citation

> US National Institutes of Health, RePORTER application 10372682, Integrators of Metastatic Potential (3R01CA238042-03S1). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10372682. Licensed CC0.

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