# Alcohol-related sleep disturbances and circuit dynamics of arousal neuropeptides

> **NIH NIH R00** · STANFORD UNIVERSITY · 2021 · $249,000

## Abstract

Project Summary
Alcoholism is a chronic disorder with severe consequences to physiology of affected individuals, and far-
reaching effects on society in general. In particular, further research is required to advance scientific
knowledge of the intricate neurobiology underlying the relationship between excessive alcohol drinking and
deficits in sleep, a fundamental component of life. This proposal will integrate in vivo measurements of neural
calcium activity with electroencephalogram sleep recordings in animal models of long-term, free-choice
intermittent heavy alcohol exposure, in order to establish (or refute) causal relationships between the
hypothalamic hypocretin system, extended amygdala corticotropin-releasing factor system, and stress-like
states of hyperarousal (disrupted sleep) during alcohol withdrawal. Knowledge gained from the proposed
experiments will inform future strategies for mitigation of drug abuse and relapse.

## Key facts

- **NIH application ID:** 10373277
- **Project number:** 4R00AA025677-03
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** William J Giardino
- **Activity code:** R00 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $249,000
- **Award type:** 4N
- **Project period:** 2021-06-01 → 2024-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10373277

## Citation

> US National Institutes of Health, RePORTER application 10373277, Alcohol-related sleep disturbances and circuit dynamics of arousal neuropeptides (4R00AA025677-03). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10373277. Licensed CC0.

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