# CHASM: Children Hospitalizations After SARS-COV-2 for MIS-C

> **NIH AHRQ R03** · CINCINNATI CHILDRENS HOSP MED CTR · 2021 · $99,995

## Abstract

PROJECT SUMMARY
Overview of Project: Multisystem Inflammatory Syndrome in Children (MIS-C) is a serious
condition affecting children after COVID-19 infection. MIS-C commonly results in severe critical
illness and even death. We will provide an examination of MIS-C in 49 children’s hospitals
throughout the United States. In this proposal, we will advance knowledge on MIS-C severity of
illness as well as evaluate initial treatment regimens. We will describe differences in initial
treatment decisions and their associated risk of treatment failure. The completion of this work
will result in new knowledge regarding the most effective initial treatments for MIS-C.
Environment: Cincinnati Children’s Hospital Medical Center (CCHMC) is the second largest
pediatric recipient of funding from the NIH. Drs. Auger and Brady are members of the Division of
Hospital Medicine at CCHMC. This division is among the most research-oriented pediatric
hospital medicine divisions in the country with a focus on hospital quality and safety and with
four faculty members currently on AHRQ grants. Both PIs receive extensive support including
computers and software, biostatistical advisors, data management support, clinical research
coordinators, grants management support, and discretionary funds. Drs. Auger and Brady are
also a members of CCHMC’s James M. Anderson Center for Health Systems Excellence, a
nationally renowned research division that focuses on assessing and improving pediatric health
care delivery. This proposal additionally leverages the vast resources of the Children’s Hospital
Association (CHA) and its experienced biostatistical and data analysis team. Dr. Matt Hall as the
principal biostatistician at CHA has a decade-plus experience using the Pediatric Health
Information System (PHIS) to ask and answer epidemiologic and comparative effectiveness
research questions. He has an extensive record of collaboration with the entire research team,
having coauthored over 100 publications with members of this team.
Summary: This innovative proposal will generate new, significant knowledge on both the
epidemiology and management of MIS-C. This critically important information is foundational for
future randomized controlled trials for MIS-C treatment and for development of evidence-based
treatment algorithms and pathways.

## Key facts

- **NIH application ID:** 10373711
- **Project number:** 1R03HS028102-01A1
- **Recipient organization:** CINCINNATI CHILDRENS HOSP MED CTR
- **Principal Investigator:** Katherine Ann Scott Auger
- **Activity code:** R03 (R01, R21, SBIR, etc.)
- **Funding institute:** AHRQ
- **Fiscal year:** 2021
- **Award amount:** $99,995
- **Award type:** 1
- **Project period:** 2021-09-30 → 2022-09-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10373711

## Citation

> US National Institutes of Health, RePORTER application 10373711, CHASM: Children Hospitalizations After SARS-COV-2 for MIS-C (1R03HS028102-01A1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10373711. Licensed CC0.

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