# Data Management, Biostatistics & Bioinformatics Core D

> **NIH NIH U19** · UNIVERSITY OF PENNSYLVANIA · 2021 · $452,683

## Abstract

Core D: Data Management, Biostatistics and Bioinformatics Core
Core Leader: Sharon X. Xie; Co-Investigator: Li-San Wang
Summary/Abstract: Data Management, Biostatistics and Bioinformatics Core D
The Data Management, Biostatistics and Bioinformatics Core D is an integral part of this National on Aging
(NIA) U19 “Center On Alpha-synuclein Strains In Alzheimer Disease & Related Dementias” at the University of
Pennsylvania (Penn) Perelman School of Medicine (PSOM). The goal of Core D is to support the data
management, database, statistics, bioinformatics, and related computational needs of Penn U19 Center
investigators, as well as provide data sharing support to investigators outside the U19 Center and Penn. The
services provided by Core D include: (a) support for data form/questionnaire design and development,
database development and management, data entry, database audit trail, database security, database backup,
and stringent data quality control procedures, (b) computing and programming support for all Penn U19 Center
activities, including implementation and integration of hardware and software upgrades necessary for data
management and research, routine and archival off-site backup of computing systems central to the Center, (c)
biostatistical support for all study aspects of Projects and Cores from inception to publication, including
development of study design, performing sample size and power calculations, and performing analyses of the
Center data, (d) integration of bioinformatics and biostatistics expertise to support analysis of genetic data and
development of multimodal risk prediction models, (e) development of new statistical methodologies and
extension of existing methodologies where needed for analyses of Center data, (f) Implementation of data
sharing between the U19 Center and other researchers outside the U19 Center and Penn in partnership with
the NIA. Thus, Core D plays an important and significant role that is critical to the progress of research and the
conduct of studies in the Penn U19 Center, and it will foster collaborative interactions between the Penn U19
Center and researchers outside the Center.

## Key facts

- **NIH application ID:** 10373919
- **Project number:** 5U19AG062418-03
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** Sharon Xiangwen Xie
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $452,683
- **Award type:** 5
- **Project period:** 2019-09-30 → 2024-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10373919

## Citation

> US National Institutes of Health, RePORTER application 10373919, Data Management, Biostatistics & Bioinformatics Core D (5U19AG062418-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10373919. Licensed CC0.

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