# Mutant Mouse/Viral Vector Core

> **NIH NIH P30** · VIRGINIA COMMONWEALTH UNIVERSITY · 2022 · $305,774

## Abstract

Project Summary – Mutant Mouse/Viral Vector Core 
The objective of this Core is to provide expert advice from the talented team of co-investigators, necessary 
training, and the infrastructure to utilize molecular biological approaches to create genetically engineered 
mouse models that will increase the depth and breadth of existing drug abuse research and stimulate new 
research at Virginia Commonwealth University and throughout the scientific community. Additionally, it will 
provide a mechanism for scientists both within and outside of the drug abuse field to interact to develop new 
research projects. Specifically, this Core will provide investigators the necessary training, tools, and 
expertise to: 1) create novel genetically modified mice, not currently available through other sources; 2) 
maintain mice in a repository in which available mouse lines will be bred, genotyped, and transferred to the 
investigator upon weaning; 3) cryogenically preserve mouse lines for use in future studies; 4) develop viral- 
vectors to over-express, knock-down or deliver dominant negative forms of study genes chosen by 
collaborating investigators; and· 5) deliver viral vectors stereotaxically into specific brain regions of interest 
and verify the extent of the manipulation. Overall, this Core will provide new services to multiple investigators, 
with the goals of providing state-of-the-art molecular biological tools to investigate drugs of abuse, facilitate 
collaborations, and provide value to drug abuse researchers.

## Key facts

- **NIH application ID:** 10374824
- **Project number:** 5P30DA033934-09
- **Recipient organization:** VIRGINIA COMMONWEALTH UNIVERSITY
- **Principal Investigator:** ARON H LICHTMAN
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $305,774
- **Award type:** 5
- **Project period:** 2013-12-01 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10374824

## Citation

> US National Institutes of Health, RePORTER application 10374824, Mutant Mouse/Viral Vector Core (5P30DA033934-09). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10374824. Licensed CC0.

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