# Passive heat therapy for lowering systolic blood pressure and improving vascular function in mid-life and older adults

> **NIH NIH R01** · UNIVERSITY OF COLORADO · 2022 · $654,978

## Abstract

Project Summary
 Age-related increases in systolic blood pressure (SBP) and vascular dysfunction are major factors driving
cardiovascular diseases (CVD) in “mid-life” (50-64 years) and older (65+) (ML/O) adults. Much of the elevated
CVD risk occurs in ML/O adults with casual (resting) SBP in the “elevated” (120-129 mmHg) and stage 1
hypertension (130-139 mmHg) ranges and is associated with: a) impaired endothelial function (decreased
brachial artery flow-mediated dilation [FMDBA]); and b) stiffening of the large elastic arteries (increased carotid-
femoral pulse wave velocity [CFPWV], i.e., aortic stiffness, and carotid artery β-stiffness index), all mediated by
excess reactive oxygen species (ROS)-related oxidative stress, which reduces nitric oxide (NO) bioavailability.
 Current guidelines recommend that SBP in these ranges be treated with lifestyle strategies for ~3 months
prior to considering drug therapy. We have shown in healthy young adults that passive heat therapy (hot
water immersion to raise core temperature from ~37.0 to 38.5-39.0°C) is safe and may improve SBP and
vascular function. We recently completed a small pilot trial (n=23) in ML/O adults and found that 30 sessions
of heat therapy over ~10 weeks was safe/well-tolerated, reduced casual SBP (~10 mmHg) and ambulatory 24-
h SBP (~6 mmHg), increased FMDBA and NO bioavailability, and reduced CFPWV, carotid β-stiffness and
vascular oxidative stress. Exposing endothelial cells in culture to serum obtained from subjects after (vs.
before) heat therapy suppressed basal ROS production and increased acetylcholine-stimulated NO production,
indicating that changes in “circulating factors” may, at least in part, transduce the CV benefits of heat therapy.
 As the required next step in translation of passive heat therapy to eventual clinical practice, we propose
a larger, properly powered, randomized, sham-controlled, parallel group design, single-site clinical trial
to assess the efficacy, safety, underlying mechanisms, and potential lasting effects of passive heat therapy (36
x 60-min sessions over ~12 weeks) vs. sham (thermoneutral water immersion) for decreasing casual and 24-h
SBP and improving vascular function in ML/O men and women with elevated SBP/stage 1 hypertension.
 To determine before, after passive heat therapy vs. sham (control), and after 4 and 12 weeks of follow-up:
Aim 1: Casual (resting) and 24-h BP. Safety, tolerability, and implementation feasibility will also be assessed.
Aim 2: Vascular endothelial function (FMDBA) and aortic (CFPWV) and carotid (β-stiffness index) stiffness.
Aim 3: a) Oxidative stress-related suppression of FMDBA (acute increase in FMDBA in response to a supra-
therapeutic infusion of the ROS scavenger, vitamin C); b) markers of oxidative stress, pro-oxidant signaling,
and antioxidant defenses in endothelial cells obtained from clinical endovascular biopsy; c) abundance and
content of circulating microvesicles (MVs); and d) NO bioavailability, ROS prod...

## Key facts

- **NIH application ID:** 10375083
- **Project number:** 1R01AG073117-01A1
- **Recipient organization:** UNIVERSITY OF COLORADO
- **Principal Investigator:** DOUGLAS R SEALS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $654,978
- **Award type:** 1
- **Project period:** 2022-04-01 → 2027-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10375083

## Citation

> US National Institutes of Health, RePORTER application 10375083, Passive heat therapy for lowering systolic blood pressure and improving vascular function in mid-life and older adults (1R01AG073117-01A1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10375083. Licensed CC0.

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