# Center for 3D Imaging in Cancer Cell Biology

> **NIH NIH U54** · JOHNS HOPKINS UNIVERSITY · 2022 · $46,703

## Abstract

Administration and Coordination Core - Project Summary:
The Johns Hopkins Center for 3D Multiscale Cancer Imaging will facilitate innovation in advanced imaging
technologies that could be applied to fundamental basic and pre-clinical research problems in cancer biology.
The mission of our Administrative and Coordination (A&C) Core is to ensure that the individual Research Units
combine with synergy beyond the individual parts, to contribute to the CCBIR Network with strength beyond the
individual Center, to integrate with the NCI and the cancer research community, and to be a partner with patient
advocates to connect basic research with improved patient outcomes. The Center brings together preeminent
faculty from eight departments housed in two schools (Medicine and Engineering), three JHU Centers and
Institutes, and a spatial omic expert at Yale. This multidisciplinary perspective enables us to bring the latest
experimental and computational methods to bear on the most clinically relevant aspects of cancer. Center
leadership are tremendously excited about the impact of the proposed Center and this is evident in substantial
technical, administrative, and financial support provided to our team through scientific cores, administrative
support from the Provost's office and Dean's office, and over $1M in matching funds. The leadership of the
Center is strongly committed to mentoring the next generation of leaders in cancer research including those
traditionally underrepresented in biomedical research. Our JH Center includes two early-stage investigators
(ESI) as critical co-Leads of the first Technology Development Unit (Dr. Ho and Dr. Wu). Our Administrative Core
will ensure the successful execution of our ambitious mission directed by two aims. Aim 1: Scientific and Financial
Management of the Center. Drs. Wirtz and Wood will have overall responsibility for the scientific and
administrative leadership of the Center, with support from an experienced Project Manager. A Steering
Committee including the Multiple PIs, the Unit Leads and co-Leads, and the Project Manager will meet monthly
to discuss scientific progress, challenges, and budgetary issues. The A&C Core will refine and monitor budgets,
allocating funds to each unit to achieve overall center goals. They will also take the lead on preparing timely
reports to the NIH, the Hopkins IRB, and other oversight regulatory bodies. Aim 2: Communication and Review:
External Advisory Panel (EAP), Internal Advisory Committee (IAC), Patient Advocates, and NCI. The Core will
develop and ensure timely communications and documentation within the Center and across all Centers within
the network. In addition, the Core will monitor timelines and milestones, and assign tasks to the unit leaders to
assure that milestones are met. Oversight will be provided by an EAP and the NCI. The A&C will gather annual
progress reports from the units, address any potential major changes in direction, and with patient advocates,
...

## Key facts

- **NIH application ID:** 10375191
- **Project number:** 1U54CA268083-01
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** Denis Wirtz
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $46,703
- **Award type:** 1
- **Project period:** 2021-12-01 → 2026-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10375191

## Citation

> US National Institutes of Health, RePORTER application 10375191, Center for 3D Imaging in Cancer Cell Biology (1U54CA268083-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10375191. Licensed CC0.

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