# System Biological Analyses of Innate and Adaptive Responses to Vaccination

> **NIH NIH U19** · EMORY UNIVERSITY · 2021 · $467,690

## Abstract

The research proposed in years 6 and 7 of the Emory-HIPC will build on the considerable progress made
during the first 5 years in using systems based approaches to understand the molecular networks driving
innate and adaptive immune responses to vaccination. The major focus of the work planned in years 6
and 7 is to understand the immunological mechanisms by which the recently licensed subunit vaccine for
herpes zoster (HZ, shingles) induces highly efficacious protection against shingles. HZ which is caused by
the varicella zoster virus (VZV), affects several million people/year globally, and is a significant public
health concern for the elderly. An important recent development is the development of a new subunit HZ
vaccine, which contains the recombinant glycoprotein E subunit (“gE vaccine”), adjuvanted with AS01, a
liposome-based adjuvant system containing the TLR4 agonist MPL, and the saponin, QS21 (1-4). The gE
vaccine has recently been licensed for clinical use in subjects older than 50 years, under the trade name
Shingrix®. Remarkably, the efficacy of Shingrix® is high (91%) even in 70 year old vaccinees (1-4).
Although Shingrix® has revealed superior antibody responses and greater durability of CD4+ T cell
responses to the gE vaccine, a comprehensive assessment of immune responses to the gE vaccine is
lacking. This will be achieved in Aims 1 and 2, where we will analyze the innate and adaptive responses
to Shingrix®. Importantly we will analyze these results in the context of data generated from our previous
HIPC project on immune responses induced by the live attenuated zoster vaccine, Zostavax®.
Aim 1: Systems analysis of innate responses elicited by Shingrix® in 50-60 year old and >70 year old
subjects.
Aim 2: To analyze the adaptive immune response elicited by Shingrix® in 50-59 year old and >70-85
years old subjects.

## Key facts

- **NIH application ID:** 10375723
- **Project number:** 3U19AI090023-12S1
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** Rafi Ahmed
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $467,690
- **Award type:** 3
- **Project period:** 2021-03-01 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10375723

## Citation

> US National Institutes of Health, RePORTER application 10375723, System Biological Analyses of Innate and Adaptive Responses to Vaccination (3U19AI090023-12S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10375723. Licensed CC0.

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