# Structural determinants of amyloid strain heterogeneity in distinct phenotypes of Alzheimer's disease

> **NIH NIH RF1** · CASE WESTERN RESERVE UNIVERSITY · 2021 · $400,670

## Abstract

The deposition of aggregated hyperphosphorylated tau protein in brain is directly associated with cell death and
propagation of brain pathology in Alzheimer's disease and several other neurodegenerative diseases, including
frontotemporal dementia. The major goal of the parent award RF1 AG 061797 is to elucidate the relationship
between structural properties of tau and Aβ aggregates and phenotypic variability of Alzheimer's disease and
related disorders. An important recent development is the finding that, akin to some other proteins involved in
neurodegenerative diseases, tau can undergo liquid-liquid phase separation, forming condensates in which
protein concentration is extremely high. The environment of these condensates may have a major impact on the
aggregation properies of tau, contributing to the pathogenic process. The purpose of this Administrative
Supplement is to expand the scope of studies in the parent award into this rapidly emerging area of research,
with the main specific objective to elucidate the mechanisms of tau liquid-liquid phase separation and the role of
different types of interactions in this process. The insights gained in this research should provide a necessary
foundation for future studies aimed at understanding the intricate role of liquid-liquid phase separation in
pathological aggregation of tau in Alzheimer's disease and related disorders.

## Key facts

- **NIH application ID:** 10375763
- **Project number:** 3RF1AG061797-01S1
- **Recipient organization:** CASE WESTERN RESERVE UNIVERSITY
- **Principal Investigator:** Christopher P Jaroniec
- **Activity code:** RF1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $400,670
- **Award type:** 3
- **Project period:** 2018-09-30 → 2023-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10375763

## Citation

> US National Institutes of Health, RePORTER application 10375763, Structural determinants of amyloid strain heterogeneity in distinct phenotypes of Alzheimer's disease (3RF1AG061797-01S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10375763. Licensed CC0.

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