# A Wireless micro-ECoG Prosthesis for Speech

> **NIH NIH R01** · DUKE UNIVERSITY · 2021 · $655,596

## Abstract

Project Summary / Abstract
Patients who suffer from debilitating neuromuscular disorders (e.g. amyotrophic lateral sclerosis – ALS, Locked-
in-Syndrome – LIS, and muscular dystrophies/myopathies) have difficulty or an inability to communicate through
speech leading to a detrimental loss in quality of life. Current technology using eye movements and
signals/spellers from electroencephalography (EEG) are slow and inconsistent. Neural prostheses offer an
opportunity to produce fast and accurate communication for patients suffering from neuromuscular disorders,
but success for regaining speech has been limited due to technological limitations: there is an inability to capture
the high dimensionality of the brain and an inability to record in naturalistic conditions using fully implanted,
wireless electrode arrays. To solve these challenges, we develop and optimize custom wireless micro-
electrocorticographic (µECoG) arrays with over 1,000 channels to decode speech directly from the human brain.
We will accomplish this by 1) Testing and optimizing the spatial resolution of µECoG to capture neural signals,
2) Fine-tune our machine learning algorithms to decode speech directly from the brain and 3) developing wireless
technology to enable neural prosthetic usage in naturalistic settings. High-density, high channel-count neural
interfaces will offer an unprecedented ability to decode speech from the human brain. This ability combined with
wireless technology, will allow for a new generation of speech neural prostheses.

## Key facts

- **NIH application ID:** 10375951
- **Project number:** 1R01DC019498-01A1
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** Kenneth L Shepard
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $655,596
- **Award type:** 1
- **Project period:** 2021-09-17 → 2026-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10375951

## Citation

> US National Institutes of Health, RePORTER application 10375951, A Wireless micro-ECoG Prosthesis for Speech (1R01DC019498-01A1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10375951. Licensed CC0.

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