# Lipidomics Shared Resource

> **NIH NIH P30** · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2022 · $61,757

## Abstract

LIPIDOMICS SHARED RESOURCE: SUMMARY
The mission of the Lipidomics Shared Resource (LSR) is to provide cost-effective advanced methodology,
state-of-the-art instrumentation, and expertise in the synthesis and analysis of bioactive lipids to Hollings Can-
cer Center (HCC) members. The scientific goal of the LSR is to provide resources for studying lipid metabolism
and signaling in cancer, for identifying bioactive lipids and their role in tumor cell biology, and for discovering
and evaluating drugs that target lipid metabolic processes. By providing deep exploratory as well as high
throughput lipidomic options to analyze cancer cells and tissues, combined with educational workshops, the
LSR fosters interactions among basic, clinical and population scientists at HCC. To remain at the leading edge
of an evolving field, since the last review, the LSR expanded services by investing in new equipment (Thermo
TSQ-50003, SCIEX Q-Trap triple quadrupole/ion trap, Advion TriVersa Nanomat) and transferring equipment
from the Cell & Molecular Imaging Shared Resource to LSR, adding MALDI imaging services to LSR (Bruker
Faltonics AutoFlex III linear MALDI, and AutoFLexIII MALDI TOF-TOF). During the current cycle, the LSR di-
rectly supported 45 cancer-related publications, three team science projects, multiple internally funded team-
based projects, three individual cancer grants, two translational studies, and one phase 1 clinical trial. Under
the leadership of Besim Ogretmen, PhD, the LSR has grown to become a nationally- and internationally-recog-
nized scientific resource with novel sophisticated methods for measurement and analysis of bioactive lipid mol-
ecules relevant to cancer initiation and progression. Ogretmen is a national leader in lipid biology with a partic-
ular focus on sphingolipids, including glycosphingolipids. The LSR has integrated MALDI imaging capability for
direct tissue analysis of sphingolipid species in tissues, drug distribution in tumor xenograft tissue and organs
(brain, kidney, liver), and structure confirmation of drug or metabolite of interest by collision-induced fragmenta-
tion. Thus, by combining mass spectrometry and MALDI imaging, this resource not only quantifies sphin-
golipids in tissues, but can also provide information about their cellular location and distribution in tissues. The
LSR is well poised to advance and support important emerging scientific disciplines in cancer research to HCC
members and the broader scientific community.

## Key facts

- **NIH application ID:** 10377471
- **Project number:** 5P30CA138313-14
- **Recipient organization:** MEDICAL UNIVERSITY OF SOUTH CAROLINA
- **Principal Investigator:** Besim Ogretmen
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $61,757
- **Award type:** 5
- **Project period:** 2009-04-01 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10377471

## Citation

> US National Institutes of Health, RePORTER application 10377471, Lipidomics Shared Resource (5P30CA138313-14). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10377471. Licensed CC0.

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