# PRECISE-TBI: PRE Clinical lnteragency research resourcE-TBI

> **NIH VA I50** · VA SALT LAKE CITY HEALTHCARE SYSTEM · 2022 · —

## Abstract

PROJECT SUMMARY
The overarching mission of this project is to develop a Center entitled PRE-Clinical Interagency reSearch
resourcE-Traumatic Brain Injury (PRECISE-TBI) with the mission of accelerating the development of therapies
for TBI. PRECISE-TBI will achieve this mission by utilization of an enterprise approach to meet key objectives
with targeted strategies. We will also leverage previous collaborative efforts. The organizational structure of
PRECISE-TBI incorporates elements from business models and from other research consortia. The strategic
missions of the Center are divided into five Cores and milestones will be achieved by activities of Core
Directors and members. Leadership of PRECISE-TBI will be the Core Directors (Drs. Dixon, Gurkoff,
VandeVord, Martone, LaPlaca, Harris, Floyd) and the Steering Committee Chair, Dr. Adam Ferguson.
Leadership will interact with a Steering Committee (comprised of persons representing clinical expertise, other
VA programs, other agencies, and all model types) to set objectives, milestones, and deliverables. We will
have a Community Committee to be comprised of 100+ persons with wide TBI knowledge and perspectives.
Committee members will be divided into task-oriented subcommittees, with oversight/guidance from
Leadership and the Steering Committee. Core Directors, Steering Committee Chair, and the Steering
Committee members are carefully selected to provide diversity and inclusion in TBI expertise, geographic
location, funding history, gender identity, seniority, and research focus. Expertise in both acute and chronic TBI
as well as pediatric TBI models will be included. Representatives from industry and non-profit organizations are
included in the Steering Committee. The AO/Scientific Writer will compose drafts of documents for finalizing by
Committee members. The organization structure of PRECISE-TBI connects investigators in both the Steering
Committee and in the Community Committee which facilitates efficiency and wide-range engagement. Each of
the Cores has an overarching objective that will be met by aims and milestones. The mission of the
Administration Core is to promote effective and efficient communication and interactions between all elements
of PRECISE-TBI. The working perspective is that the TBI investigators will act as both “employees” and
“customers.” This dual role is because TBI investigators will be engaged to develop (employees) and use
(customer) the consensus statements and translational roadmaps. The overarching goal of the Preclinical
Model Catalogue Core is the creation, dissemination and maintenance of an online catalogue of preclinical
models of TBI as well as create a database of preclinical TBI outcomes that are ontological to human TBI
pathologies. The Common Data Elements Core mission is to develop and then benchmark new and existing
common data elements using existing data from funded consortia and data from new endeavors. The
Informatics Core seeks to fuel knowledge disc...

## Key facts

- **NIH application ID:** 10378331
- **Project number:** 1I50BX005878-01
- **Recipient organization:** VA SALT LAKE CITY HEALTHCARE SYSTEM
- **Principal Investigator:** C EDWARD DIXON
- **Activity code:** I50 (R01, R21, SBIR, etc.)
- **Funding institute:** VA
- **Fiscal year:** 2022
- **Award amount:** —
- **Award type:** 1
- **Project period:** 2021-11-01 → 2026-10-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10378331

## Citation

> US National Institutes of Health, RePORTER application 10378331, PRECISE-TBI: PRE Clinical lnteragency research resourcE-TBI (1I50BX005878-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10378331. Licensed CC0.

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