# Cytogenetics Shared Resources Core

> **NIH NIH P30** · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · 2022 · $198,590

## Abstract

PROJECT SUMMARY/ABSTRACT— Cytogenetics Shared Resource
The Cytogenetic Shared Resource (CSR) is an SJCCC-managed Shared Resource with the overarching goal
of providing Center members with access to high-quality, comprehensive cell-based genetic assays and
associated expertise for cancer research. We accomplish this goal by collaborating with SJCCC members to
determine project goals and develop and apply customized assays and analysis to advance member research.
The CSR is directed by Marcus Valentine, who has more than 35 years of experience in cytogenetics and is a
co-author of 90 peer-reviewed scientific articles. He is supported by 2 technologists, each of whom has more
than 30 years of experience in the field. Examples of new assays developed in the current project period include
assays for identifying the presence of numerous clinically actionable gene-fusion events in ALL (HMP, Roberts
et al., NEJM, 2014) and assignment of hundreds of genes to specific epigenetic compartments within the retina
(DBSTP, Aldiri et al., Neuron, 2017). The impact of the CSR on the cancer research of the Programs is evidenced
by the high level of collaborative publications and key scientific contributions in high-impact journals such as
Cancer Cell (n=5), Blood (n=3), and Nature Communications (n=4). During the current funding period, research
from 53 publications from January 2013–December 2017 utilized the CSR, representing 15 (28%)
interprogrammatic and 18 (34%) intraprogrammatic collaborations. These included publications from 4 of the 5
Programs: DBSTP (n=9), HMP (n=22), CBP (n=19), and NBTP (n=24). During the index year (FY2017), 85% of
all investigators using the CSR were SJCCC members (22/26). Goals for the next period include continuing to
develop and apply new assays to support the cancer research of SJCCC members in emerging areas such as
epigenetics. In addition, to support the precision medicine goals of the SJCCC strategic plan, the CSR will work
collaboratively with SJCCC members to develop and validate new assays as new gene rearrangements are
discovered, and transfer these assays for implementation in patient diagnostics. Lastly, the CSR will monitor
technical improvements in the field (eg., advanced microscopy) that may be appropriate for implementation in
the CSR.

## Key facts

- **NIH application ID:** 10378569
- **Project number:** 5P30CA021765-43
- **Recipient organization:** ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- **Principal Investigator:** Marcus Valentine
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $198,590
- **Award type:** 5
- **Project period:** 1997-04-01 → 2024-02-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10378569

## Citation

> US National Institutes of Health, RePORTER application 10378569, Cytogenetics Shared Resources Core (5P30CA021765-43). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10378569. Licensed CC0.

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