# Neural Computations Underlying Vocal Sensorimotor Transformations

> **NIH NIH R01** · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2022 · $662,064

## Abstract

Project Summary/Abstract
 This project aims to investigate the circuit mechanisms enabling an ethologically relevant sensorimotor
transformation. Specifically, we characterize the neural basis for rapid vocal exchanges in the singing
mouse (Scotinomys teguina), a highly vocal neotropical rodent species capable of producing an audible,
stereotyped song. Pairs of S. teguina often precisely coordinate the timing of their vocalizations in a process
known as countersinging. In preliminary work, we revealed a short-latency pathway from an orofacial region
of motor cortex to the muscles involved in vocal production. In this proposal, we will test the hypothesis that
neural dynamics in motor cortex, guided by selective acoustic cues, can modify downstream song
production circuits to enable rapid vocal communication across individuals. From these studies, we will
perform the first characterization of the circuit mechanisms underlying rapid vocal exchanges in a
mammalian model system.
 In Aim 1, we will characterize the acoustic aspects of song that elicit countersinging behavior. We will
examine responses to the playback of a range of natural and synthetic sensory stimuli to test perceptual
boundaries and factors leading to vocal responsiveness.
 In Aim 2, we will use several complementary perturbations to address the role of motor cortex on vocal
production and countersinging coordination.
 In Aim 3, we will use population recordings to examine the responses of cortical neural populations
during vocal perception and production. We will then characterize the broader neural circuitry leading to
countersinging by uncovering both upstream and downstream synaptic partners.

## Key facts

- **NIH application ID:** 10378771
- **Project number:** 5R01NS113071-04
- **Recipient organization:** NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- **Principal Investigator:** MICHAEL A LONG
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $662,064
- **Award type:** 5
- **Project period:** 2019-07-15 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10378771

## Citation

> US National Institutes of Health, RePORTER application 10378771, Neural Computations Underlying Vocal Sensorimotor Transformations (5R01NS113071-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10378771. Licensed CC0.

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