# Tailored Retention and Engagement for Equitable Treatment of OUD and Pain (TREETOP)

> **NIH NIH RM1** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2021 · $4,798,445

## Abstract

PROJECT SUMMARY/ABSTRACT: The Tailored Retention and Engagement for Equitable Treatment of OUD
and Pain (TREETOP) clinical research center at the University of Pittsburgh (Pitt) is part of the NIH IMPOWR
network. TREETOP draws on the NIDA Clinical Trials Network Appalachian (Pennsylvania & West Virginia)
and Western States (Oregon) Nodes and the Community-based OUD and Pain Enhanced treatment (COPE)
collaborative (Baltimore, Maryland) to develop effective, equitable, and sustainable interventions for chronic
pain and OUD. Our overall goal is to improve treatment for comorbid chronic pain and OUD across the OUD
Treatment Cascade, prioritizing two disproportionately impacted communities for whom equitable
implementation of effective interventions can be challenging: rural and Black communities. We will achieve our
overall goal through the integrated contributions of 5 center components as follows: 1) Research Site
Overview, Management, and Operations - Our diverse multidisciplinary team has extensive experience with
multisite clinical trials as well as in TREETOP’s two emphasis areas, health equity and implementation
science. 2) Engagement and Outreach - Our TREETOP Stakeholder Consultation Board (SCB) includes
representatives with a variety of perspectives and lived experiences from each clinic and community partnering
in our studies and will serve as active participants on the research team. 3) Engagement/Retention Research
Projects - Both projects share the central premise that treating chronic pain improves pain and OUD
outcomes, tailor a pain self-management (PSM) intervention to patients with co-morbid chronic pain and OUD,
and evaluate both the intervention effectiveness and the barriers and facilitators to equitable and sustained
implementation of the intervention through the Health Equity Implementation Framework. Specifically, the
Engagement research project investigates whether PSM can improve pain and engage primary care patients
in medication treatment for OUD, while the Retention project investigates whether PSM and/or flexibly dosed
buprenorphine/naloxone can improve pain and retention in treatment among patients who have already
initiated care in office-based addiction treatment programs. 4) Data Collection, Management, and
Harmonization - The Data Core will be led by investigators with a track record of success in the measurement
and analysis of patient-reported outcomes and in leading clinical trials and data coordinating centers, and
includes national leaders in the PROMIS Health Organization. 5) Pilot Projects - Our Pilot program includes 3
initial studies on pain measurement, chronic pain/OUD treatment implementation in specialty settings, and
chronic pain and OUD stigma, and then follows a standard protocol for soliciting and reviewing future pilot
projects addressing health equity and implementation science. Overall Impact: Our TREETOP investigators
and SCB will collaborate to advance the science of sustainably and equitably ...

## Key facts

- **NIH application ID:** 10378923
- **Project number:** 1RM1DA055311-01
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** Megan Hamm
- **Activity code:** RM1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $4,798,445
- **Award type:** 1
- **Project period:** 2021-09-30 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10378923

## Citation

> US National Institutes of Health, RePORTER application 10378923, Tailored Retention and Engagement for Equitable Treatment of OUD and Pain (TREETOP) (1RM1DA055311-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10378923. Licensed CC0.

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