# Biomarkers of Early Experimental Glaucoma - Resubmission - 1

> **NIH NIH R01** · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2022 · $692,774

## Abstract

PROJECT SUMMARY
Glaucoma is a leading cause of vision morbidity and blindness with irreversible damage to retinal ganglion
cells. Identifying biomarkers for early detection of glaucoma are paramount for timely initiation of treatment for
preservation of functional vision throughout life. This project uses a chronic ocular hypertension animal model
that provides unique insight into the changes the eye undergoes as it transitions from health to fully-manifest
glaucoma. Using advanced ocular imaging technologies and state-of-the-art image processing methods we will
monitor longitudinal structural and functional ocular changes, both global and local, of each animal as they
develop glaucoma. We will determine the response of the optic nerve to two of the major causes of glaucoma –
intraocular pressure (IOP) and intracranial pressure (ICP) – by acutely modulating these pressures and
quantifying changes in optic nerve deformation at different time points along the course of the follow-up. This
will allow determining the role of these pressures at the various stages of glaucoma development and changes
in the optic nerve resulting from chronic exposure to elevated IOP, also known as remodeling. Lastly, we will
identify structural and functional features and locations in the eye that are associated with future development
of glaucomatous damage.
 The outcome of this project will provide insight into sensitive ocular biomarkers and their timeline of
occurrence for early detection of glaucoma. Our model and tools ensure that the results can be translated to
humans with substantial impact on clinical care.

## Key facts

- **NIH application ID:** 10379307
- **Project number:** 5R01EY030770-03
- **Recipient organization:** NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- **Principal Investigator:** Gadi Wollstein
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $692,774
- **Award type:** 5
- **Project period:** 2020-04-01 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10379307

## Citation

> US National Institutes of Health, RePORTER application 10379307, Biomarkers of Early Experimental Glaucoma - Resubmission - 1 (5R01EY030770-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10379307. Licensed CC0.

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