# Exercise, MANF, and Chemical-Induced Neurodegeneration

> **NIH NIH R00** · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2021 · $20,849

## Abstract

SUMMARY
The main goal of this research training plan for Ms. Jasmin Johnson's academic and scientific development is
to define the underlying mechanisms driving exercise protection from rotenone-induced neurodegeneration
and exacerbation of 6-hydroxydopamine-induced neurodegeneration. This research goal is related to the
expansion of studies proposed in Specific Aim 3 of the parent grant. This proposal is designed to the test the
novel hypothesis that increased baseline ROS from long-term exercise conditioning sensitizes dopamine
neurons to the acute oxidative challenge with 6-hydroxydopamine, while providing protection from
mitochondrial inhibition by rotenone. In addition to a robust and rigorous research training plan involving
innovative new reagents, there is a strong mentoring plan that supports Ms. Jasmin Johnson's future career
plans in a strong scientific and academic environment within the PI's laboratory and supported by the Co-
Mentor. This supplemental application will provide increased diversity of development of a minority researcher
as a biomedical clinician scientist.

## Key facts

- **NIH application ID:** 10380263
- **Project number:** 3R00ES029552-03S1
- **Recipient organization:** MEDICAL UNIVERSITY OF SOUTH CAROLINA
- **Principal Investigator:** Jessica Helene Hartman
- **Activity code:** R00 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $20,849
- **Award type:** 3
- **Project period:** 2021-08-09 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10380263

## Citation

> US National Institutes of Health, RePORTER application 10380263, Exercise, MANF, and Chemical-Induced Neurodegeneration (3R00ES029552-03S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10380263. Licensed CC0.

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