# Project 3 - Flavivirus - UTMB

> **NIH NIH U19** · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2022 · $937,499

## Abstract

Summary
Many flaviviruses are significant human pathogens, among which dengue virus is the most
important mosquito-borne viral pathogen with over 390 million infections per year. Apart from
dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, tick-borne
encephalitis virus, and recently Zika virus cause global outbreaks and epidemics, posing constant
threats to public health. No FDA-approved antiviral drug is currently available to treat any flavivirus
infection, and vaccines are lacking against several family members. Thus, the development of
flavivirus antiviral therapy is a public health priority. The goal of this proposal is to develop
direct antiviral agents (DAAs) for flavivirus therapy. We will pursue three Specific Aims to
develop flavivirus DAAs. Aim 1. Develop preclinical DAAs targeting flavivirus capsid and NS4B
protein. Aim 2. Identify novel Nuc DAAs with pan-flavivirus activity. Aim 3. Evaluate combination
therapy directed against flavivirus infection. We will deliver the proposed milestones by combining
the cutting-edge biology from academia and drug discovery acumen from industry with clear
go/no-go criteria.

## Key facts

- **NIH application ID:** 10380668
- **Project number:** 5U19AI142759-04
- **Recipient organization:** UNIVERSITY OF ALABAMA AT BIRMINGHAM
- **Principal Investigator:** PEI-YONG SHI
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $937,499
- **Award type:** 5
- **Project period:** 2019-03-07 → 2024-02-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10380668

## Citation

> US National Institutes of Health, RePORTER application 10380668, Project 3 - Flavivirus - UTMB (5U19AI142759-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10380668. Licensed CC0.

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