# Cytometry and Microscopy Shared Resource

> **NIH NIH P30** · CASE WESTERN RESERVE UNIVERSITY · 2022 · $215,420

## Abstract

The Cytometry and Microscopy Shared Resource (Cytometry SR) is an essential asset to Case Comprehensive 
Cancer Center (Case CCC) members' research, illustrated by the breadth of scientific program involvement and 
reflected in the large number of investigators who use this Shared Resource (SR). Last year alone, over 300 
investigators, 37% of whom were Case CCC members, accounting for 40% of total usage, from all 7 of the Case 
CCC Programs used the SR. The mission of the Cytometry SR is to support cell-based assays in basic, 
translational, and clinical cancer research and clinical trials. This multi-site SR, jointly supported and managed 
by the Case Comprehensive Cancer Center (Case CCC), Case Western Reserve University (CWRU) School of 
Medicine (SOM), University Hospitals (UH), and Cleveland Clinic (CC) Lerner Research Institute (LRI), provides 
formal access to expensive instruments, and professional expertise and assistance in the areas of cytometry, 
microscopy, and cell sorting. The Specific Aims of the Cytometry SR are to: 
 1. Provide well-maintained flow cytometers, cell sorters, microscopes, and associated equipment. 
 2. Provide training and consultation by cytometry and microscopy professional staff. 
 3. Provide full or partial cell-based assay development to support clinical investigators. 
At last review, the Cytometry SR was rated Excellent to Very Good Merit. Throughout the current funding cycle 
(2012-2016), the Cytometry SR provided services to 484 registered users, 132 (27%) of whom are Case CCC 
members, representing all 7 of the Case CCC programs. 
The Cytometry SR provides current, well-maintained instruments that perform within the manufacturer’s 
specifications and are compliant with the safety guidelines from Environmental Health and Safety (EHS), 
Departments (CWRU, CC), and NIH. The SR Director, Co-Directors, Manager, and Assistants (collectively, Staff) 
provide professional consultation, research management, and training at any level to support research programs 
and grant applications. SR commitment to assay development ranges from consults to full responsibility. Through 
the Cytometry SR, Case CCC members have access to world class, comprehensive microscopy services; the 
Cytometry SR has successfully implemented a “Full Service” facility that is designed to support clinical trials by 
providing correlative assays (ie, design, development, optimization, and/or validation, as required by the user). 
The Cytometry SR provides high quality and essential cell imaging services to multiple investigators across the 
Case CCC. Use of distant SRs would be inefficient and uncertain, and principle investigators could not complete 
the aims of NIH grants without access to cytometry and microscopy.

## Key facts

- **NIH application ID:** 10380701
- **Project number:** 5P30CA043703-32
- **Recipient organization:** CASE WESTERN RESERVE UNIVERSITY
- **Principal Investigator:** Brian T. Grimberg
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $215,420
- **Award type:** 5
- **Project period:** 1997-08-01 → 2023-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10380701

## Citation

> US National Institutes of Health, RePORTER application 10380701, Cytometry and Microscopy Shared Resource (5P30CA043703-32). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10380701. Licensed CC0.

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