# Radiation Resources Shared Resource

> **NIH NIH P30** · CASE WESTERN RESERVE UNIVERSITY · 2022 · $49,132

## Abstract

RADIATION RESOURCES SHARED RESOURCE 
PROJECT SUMMARY/ABSTRACT 
The Radiation Resources Shared Resource (Radiation SR) is an essential asset to Case Comprehensive Cancer 
Center (Case CCC) members' research, illustrated by the breadth of scientific program involvement and reflected 
in the number of investigators who use this SR. Last year, almost 30 investigators, 69% of whom were Case 
CCC members, accounting for 71% of total usage, from 6 out of the Center’s 7 Programs used the SR. The 
facility has the overall goal of providing experimentally useful sources of ionizing radiation to researchers, with 
the expertise of radiobiology for experimental design and oversight. The Radiation SR provides instrumentation, 
consultation, and training to investigators who need to irradiate samples, cells or animals in their research. Case 
CCC investigators have designed, implemented, and published methods to adapt clinical radiosurgery devices 
for use in small animal experiments. These include CyberKnife and Gamma Knife machines that are currently in 
use by researchers to deliver radiotherapy to animals with great precision. The Specific Aims of the Radiation 
SR are to: 
1. Maintain, calibrate, and operate ionizing radiation-producing devices for cancer researchers. 
2. Provide consultation to users about instrumentation, services, training requirements, experimental design, 
 and provide support for implementation of new security regulations. 
3. Train new users in proper and safe operation of Radiation SR equipment. 
4. Allow investigators to develop pre-clinical models with novel technology that enables clinical activities. 
The Radiation SR has been successful in its mission, and was rated Outstanding to Exceptional Merit at the last 
review. Throughout the current funding cycle (2012-2016), the Radiation SR provided services to 75 registered 
users, 45 (60%) of whom are Case CCC members, representing all 7 of the Case CCC programs. 
The Radiation SR provides basic irradiation services to support studies investigating 1) radiobiology in cancer; 
2) properties of bone marrow biology; and 3) studies in which bone marrow ablation or cell irradiation is used as 
a sterilization tool. Due to the close relationship of the Radiation SR Director and Department of Radiation 
Oncology, the Radiation SR also facilitates the use of clinical irradiation devices for preclinical small animal 
research. This SR is managed and supported by the Case Comprehensive Cancer Center (Case CCC), and the 
facility’s user base consists primarily of Case CCC members. The Radiation SR is the only radiation facility on 
the campus of Case Western Reserve University (CWRU), and formal access is provided across institutions to 
all Case CCC investigators.

## Key facts

- **NIH application ID:** 10380707
- **Project number:** 5P30CA043703-32
- **Recipient organization:** CASE WESTERN RESERVE UNIVERSITY
- **Principal Investigator:** RAYMOND F MUZIC
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $49,132
- **Award type:** 5
- **Project period:** 1997-08-01 → 2023-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10380707

## Citation

> US National Institutes of Health, RePORTER application 10380707, Radiation Resources Shared Resource (5P30CA043703-32). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10380707. Licensed CC0.

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