# The Center for Therapeutic Targeting of EWS-oncoproteins

> **NIH NIH U54** · DANA-FARBER CANCER INST · 2021 · $198,250

## Abstract

PROJECT SUMMARY: Overall
This section is unchanged from the U54 CA231637 parent award.
The primary scientific focus of this Center is to understand the molecular underpinnings of EWS-ETS
driven Ewing sarcoma and to investigate novel treatments and therapeutic mechanisms to improve
outcomes for pediatric patients with this aggressive disease. Translation of molecular
understanding of sarcoma pathophysiology into effective new drugs in the clinic is a complex, risky
proposition that requires the coordinated efforts of a talented team of individuals with complementary skills.
This group brings expertise in Ewing sarcoma biology and the EWS-ETS oncoproteins, epigenetics and
transcription, structural biology, computational biology, chemical biology and drug development, mouse
models, preclinical experimental therapeutics, and clinical trials development. A Center mechanism is
essential to the success of this proposal. No one institution nor individual can bring mastery of the diversity of
approaches, technologies, and scientific domains needed to achieve the goals of this proposal. We have
elected to focus on understanding the fundamental inner workings of Ewing sarcoma from its
transcriptional circuits, to the direct protein interactions with EWS-FLI1, to the direct and immediate
effects of EWS-FLI1 degradation. Moreover, a strong emphasis of this proposal is on target
identification and preclinical validation, critical steps in the process of bringing forward therapies with optimal
chances for success in the clinic. The team that is assembled has all of the component pieces needed
for success. Our Center includes outstanding basic cancer biologists, chemists, computational biologists,
and translational researchers, and five pediatric oncologists. Thus, the proposed Center can catalyze basic
discovery and clinical translation by leveraging basic and clinical research talent within the Center and our
strong ties to outside academic and industrial partners.

## Key facts

- **NIH application ID:** 10382013
- **Project number:** 3U54CA231637-01S1
- **Recipient organization:** DANA-FARBER CANCER INST
- **Principal Investigator:** SCOTT A ARMSTRONG
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $198,250
- **Award type:** 3
- **Project period:** 2021-07-01 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10382013

## Citation

> US National Institutes of Health, RePORTER application 10382013, The Center for Therapeutic Targeting of EWS-oncoproteins (3U54CA231637-01S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10382013. Licensed CC0.

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