# KC Donnelly Externship–Promotion of Translational/Transdisciplinary Efforts in Graduate & Post-Doctoral Research

> **NIH NIH P42** · UNIVERSITY OF LOUISVILLE · 2021 · $15,600

## Abstract

Abstract
The overarching goal of my research is to investigate the role of volatile organic
compound (VOC) exposure on the development of cardiovascular disease (CVD).
Volatile organic compounds are gaseous chemicals present in industrial solvents,
petroleum products, automobile exhaust, tobacco smoke, and household chemicals.
VOCs are abundant at several Superfund and hazardous waste sites. Population based
studies at the University of Louisville SRP show that VOCs, such as 1,3-butadiene (BD),
used in the production of synthetic rubber, are positively associated with sub-clinical
markers of cardiopulmonary injury (endothelial cell and lung microparticles) and
proinflammatory cytokines. These associations are also accompanied by a decrease in
endothelial progenitor cells, reflecting an impaired endothelial repair capacity. Studies
performed by Dr. Arthur Penn (LSU SRP) have demonstrated that exposure to 1,3-
butadiene via inhalation exacerbated atherosclerosis in cockerels.1 It is unclear whether
cardiovascular injury of 1,3-butadiene is due to direct effects of the chemical or
secondary effects of 1,3-butadiene-induced pulmonary toxicity. We will be assessing the
toxicity of BD using a ‘state of the art’ air-liquid interface (ALI) cell exposure system
(Vitrocell).

## Key facts

- **NIH application ID:** 10382018
- **Project number:** 3P42ES023716-05S1
- **Recipient organization:** UNIVERSITY OF LOUISVILLE
- **Principal Investigator:** Sanjay Srivastava
- **Activity code:** P42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $15,600
- **Award type:** 3
- **Project period:** 2017-09-01 → 2023-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10382018

## Citation

> US National Institutes of Health, RePORTER application 10382018, KC Donnelly Externship–Promotion of Translational/Transdisciplinary Efforts in Graduate & Post-Doctoral Research (3P42ES023716-05S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10382018. Licensed CC0.

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