# Nutrition for Precision Health, powered by the All of Us Research Program:  Research Coordinating Center

> **NIH NIH U24** · RESEARCH TRIANGLE INSTITUTE · 2022 · $3,499,159

## Abstract

PROJECT SUMMARY/ABSTRACT
The overarching goal of the proposed RTI International–Cornell Research Coordinating Center (RCC) is to
provide seamless operational support and multidisciplinary experience for building consensus in the Nutrition
for Precision Health Consortium (NPHC). In the 1-year planning phase, we will prioritize efficiency and
objectivity in facilitating the design of diet modules (1: usual dietary assessment; 2: controlled feeding dietary
intervention; and 3: domiciled dietary intervention) nested in All of Us and their research protocols. In the 4-
year implementation phase, we will facilitate the implementation of Modules 1–3, enable the flow of quality
data and specimens across the NPHC, and integrate curated, Artificial intelligence (AI)–ready data into the
All of Us Researcher Workbench, using our established data coordination processes and systems.
Innovations in our approach include tools for conducting dietary studies in hard-to-reach populations,
idiographic (or subject-as-own-control) clinical trials, and wearables research tools and analytics.
Specifically, the proposed RCC will excel in administrating and coordinating NPHC and its research
initiatives, clinical interventions, and data and biospecimen sharing, as follows:
 Aim 1: Optimize the scientific rigor of Modules 1–3
 Aim 2: Ensure NPHC study data are FAIR (Findable, Accessible, Interoperable, and Reusable)
 Aim 3: Enable seamless data collection, curation, and transfer including to the Researcher Workbench
 Aim 4: Minimize time to launch of Modules 1–3
 Aim 5: Maximize the efficiency of consortium communications and collaborations
NPHC is being launched to address major research gaps in nutrition; the nature of these gaps and the
complexity of the NPHC activities cannot be underscored enough. RCC will be led by Multiple Principal
Investigators with complementary expertise in coordinating center and multisite leadership and biostatistics
(Dr. Gantz at RTI) and nutritional intervention and clinical expertise (Dr. Mehta at Cornell University) with the
support of a strong and diverse team, organized around cores for Design and Analytics, Data Curation and
Systems, and Study Implementation. Other key components include single IRB and medical safety
monitoring. The RCC will also benefit from our collective institutional strengths, with an expert pool of wide-
ranging research and clinical backgrounds pertinent to the NPHC (e.g., omics, bioinformatics, AI, clinical trial
intervention, nutritional assessment). The proposed RCC is immediately and amply prepared to support to
NPHC in its mission to develop clinically meaningful algorithms that predict individual responses to food and
dietary patterns and to improve health across diverse U.S. populations.

## Key facts

- **NIH application ID:** 10382053
- **Project number:** 1U24HD107676-01
- **Recipient organization:** RESEARCH TRIANGLE INSTITUTE
- **Principal Investigator:** MARIE G GANTZ
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $3,499,159
- **Award type:** 1
- **Project period:** 2021-12-01 → 2026-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10382053

## Citation

> US National Institutes of Health, RePORTER application 10382053, Nutrition for Precision Health, powered by the All of Us Research Program:  Research Coordinating Center (1U24HD107676-01). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10382053. Licensed CC0.

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