# Anti-inflammatory Activity of a Systemic STING Inhibitory Non-Nucleotide

> **NIH NIH R41** · STINGINN, LLC · 2022 · $300,000

## Abstract

PROJECT SUMMARY
Cellular innate immune sensors, such as STING (STIMULATOR OF INTERFERON GENES), have evolved to
detect microbial infection of the cell. STING controls the potent cytosolic DNA-stimulated innate immune
pathways and is activated by cyclic dinucleotides (CDNs) such as cyclic di-GMP and cyclic-di-AMP secreted by
intracellular bacteria following infection. Alternatively, STING can be activated by cyclic GMP-AMP (cGAMP)
generated by a cellular cGAMP synthase cGAS (MB21D1) after association with aberrant cytosolic dsDNA
species, which can include microbial DNA or self-DNA leaked from the nucleus. Association with CDNs enables
STING to activate the production of type I interferon (IFN) and pro-inflammatory cytokines, which facilitate
adaptive immunity. The activation of STING is critical for protection against microbial infection and cancer.
However, chronic STING activation is a leading cause of autoinflammatory disease such as severe systemic
lupus erythematosus (SLE), STING associated vasculopathy with onset in infancy (SAVI) inflammation of the
gut, tissue transplant rejection and others. Here, we describe a new generation of novel small STING antagonists
that inhibit STING signaling, for evaluation as anti-inflammatory therapeutic agents. The compounds have been
generated by STINGINN LLC, based in Miami, in collaboration with the University of Miami School of Medicine,
FL.

## Key facts

- **NIH application ID:** 10382621
- **Project number:** 1R41AI167270-01A1
- **Recipient organization:** STINGINN, LLC
- **Principal Investigator:** GLEN N BARBER
- **Activity code:** R41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $300,000
- **Award type:** 1
- **Project period:** 2021-12-17 → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10382621

## Citation

> US National Institutes of Health, RePORTER application 10382621, Anti-inflammatory Activity of a Systemic STING Inhibitory Non-Nucleotide (1R41AI167270-01A1). Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/grant/nih/10382621. Licensed CC0.

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