# Research Supplement for Kennelia Mellanson

> **NIH NIH RF1** · STATE UNIVERSITY NEW YORK STONY BROOK · 2021 · $57,052

## Abstract

ABSTRACT
Here we apply for a research supplement to our R01 grant from the NIA, submitting it in response to
PA-21-071 which is directed at fostering diversity in scientific research workforce and developing the
careers of eligible investigators. We present a detailed plan to advance the professional career of
Kennelia Mellanson, a graduate student in the laboratory. Kennelia’s current project focuses on novel
quantitative approaches to determine the key components of the ventricular and glymphatic system of
transport in the brain – the ciliary beat, the directional flow of the cerebrospinal fluid (CSF), and the
structure of the brain ependymal layer – features that are critical for the efficient ventricular transport of
the CSF, and the structure of the aquaporin 4 (AQP4) channels, which serve as the key components of
the glymphatic system of transport.
Our proposal is in full alignment with the original R01 grant from the NIA “Glymphatic and CSF systems
in aging and Alzheimer’s disease”, which focuses on the mechanisms of the brain tissue homeostasis
and clearance in Alzheimer's. We now propose using our new techniques and findings on the ventricular
and glymphatic transport to determine the changes accompany aging and progression of the
Alzheimer's disease in a mouse model and to use this project as a platform for helping and directing
Kennelia Mellanson in developing her career as a researcher and a scholar. We present a detailed
plan for Kennelia’s professional development, including a detailed plan and timeline for mentorship,
manuscript and grant writing, didactic activities, improving the presentation skills, participation in
meetings and courses, and networking. Furthermore, we present a research plan for studying the key
components of the transport systems that may be compromised by aging and by Alzheimer's disease.

## Key facts

- **NIH application ID:** 10382622
- **Project number:** 3RF1AG057705-01S2
- **Recipient organization:** STATE UNIVERSITY NEW YORK STONY BROOK
- **Principal Investigator:** Helene D Benveniste
- **Activity code:** RF1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $57,052
- **Award type:** 3
- **Project period:** 2017-09-15 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10382622

## Citation

> US National Institutes of Health, RePORTER application 10382622, Research Supplement for Kennelia Mellanson (3RF1AG057705-01S2). Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/grant/nih/10382622. Licensed CC0.

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