# Evaluation and validation of a novel instrument to assess the psychosocial and drug history backgrounds of pregnant women with or without Opioid Use Disorder

> **NIH NIH R21** · STATE UNIVERSITY NEW YORK STONY BROOK · 2021 · $432,351

## Abstract

Abstract
 The COVID-19 pandemic provides an unprecedented opportunity to conduct prospective, longitudinal
investigation of the effects of Social Determinants of Health (SDoH), including Structural Racism and
Discrimination (SRD), and maternal stress on maternal physical and mental health morbidity. The Stony Brook
COVID-19 Pregnancy Experiences (SB-COPE) Study, which forms the foundation for the proposed project,
includes detailed prospective psychosocial data from over 7,400 persons who were pregnant at the beginning
of the COVID-19 pandemic (n=4,400) or at the second U.S. COVID-19 surge (n=3,000), including 1,400
persons of color. The main objectives of this Urgent Competitive Revision proposal are to prospectively
determine pandemic-related impacts on maternal stress, identify SDoH mechanisms associated with these
impacts, and investigate the effects of stress on maternal morbidity and perinatal outcomes. The proposal
seeks to extend assessment of the SB-COPE Study cohort for an additional year, and to follow participants
into the first year postpartum, including, for some, into their next pregnancy. The proposed project will: Aim 1)
Identify contributors to maternal stress during the pandemic. It is hypothesized that pregnant persons
affected by SDoH, including SRD, will experience more stress as a result of the pandemic. SDoH to be
investigated in the pandemic context include geographical disparities, race/ethnicity, relationship and economic
status, and sexual and gender identity. SRD factors include prenatal gendered racism, everyday
discrimination, and discrimination in healthcare. Stress factors include global perceived stress, pandemic-
related stress, pregnancy-specific stress, and stressful life events. Aim 2) Identify contributors to prenatal
and postpartum mental health morbidities during the pandemic. Persons with higher levels of stress are
hypothesized to report greater mental health morbidities (depression, anxiety, and obsessive-compulsive
symptoms) prenatally and in the postpartum period. Differential effects of stress types (e.g., pandemic-related
stress, stressful life events) and interactions among stress, SDoH, and SRD (including healthcare access and
quality) in predicting mental health outcomes will be examined. Aim 3) Identify pathways resulting in poorer
maternal physical health and adverse perinatal outcomes during the pandemic. It is hypothesized that
SDoH will predict greater likelihood of adverse perinatal outcomes (e.g., low birthweight, preterm birth;
emergency delivery). This association is predicted to be mediated by prenatal maternal stress, maternal health
behaviors, and healthcare access and quality. This critically timed project capitalizes on an existing, extensive
baseline dataset (including NIH common data elements), large SB-COPE Study cohorts pregnant during
critical pandemic periods, including a sizeable number of persons of color, and the highly relevant expertise of
a multidisciplinary research tea...

## Key facts

- **NIH application ID:** 10382639
- **Project number:** 3R21DA049827-02S1
- **Recipient organization:** STATE UNIVERSITY NEW YORK STONY BROOK
- **Principal Investigator:** Heidi Preis
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $432,351
- **Award type:** 3
- **Project period:** 2020-09-30 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10382639

## Citation

> US National Institutes of Health, RePORTER application 10382639, Evaluation and validation of a novel instrument to assess the psychosocial and drug history backgrounds of pregnant women with or without Opioid Use Disorder (3R21DA049827-02S1). Retrieved via AI Analytics 2026-08-17 from https://api.ai-analytics.org/grant/nih/10382639. Licensed CC0.

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