# New Directions in Palladium/Norbornene Cooperative - Instrument Supplement

> **NIH NIH R01** · UNIVERSITY OF CHICAGO · 2021 · $102,530

## Abstract

Abstract: We are engaged in the systematic efforts to exploit new, efficient, and broadly useful
palladium/norbornene (Pd/NBE) catalysis for site-specific arene mono- and di-functionalization.
Our objective in the proposed funding period includes: first to develop new classes of vicinal di-
functionalization, e.g. ortho amination, acylation, thiolation and annulation with epoxides by
discovering new classes of electrophiles; and second to address the “ortho effect” limitation
(requirement of a pre-existing ortho substituent) by developing new NBE-type ligands. The
proposed research is expected to vastly expand the toolbox for arene functionalization via site-
specifically installing functional groups at unactivated positions, which in turn would streamline
synthesis of complex biologically important molecules containing multi-substituted aromatic
scaffolds.

## Key facts

- **NIH application ID:** 10382974
- **Project number:** 3R01GM124414-04S1
- **Recipient organization:** UNIVERSITY OF CHICAGO
- **Principal Investigator:** Guangbin Dong
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $102,530
- **Award type:** 3
- **Project period:** 2018-06-01 → 2022-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10382974

## Citation

> US National Institutes of Health, RePORTER application 10382974, New Directions in Palladium/Norbornene Cooperative - Instrument Supplement (3R01GM124414-04S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10382974. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*