# Revision to the Coordinating Center for Type 1 Diabetes TrialNet

> **NIH NIH U01** · UNIVERSITY OF SOUTH FLORIDA · 2022 · $15,000,000

## Abstract

Project Summary/Abstract
This application requests support for the continuing operations of the TrialNet Coordinating
Center (TNCC) at the University of South Florida. The University of South Florida has served as
the Coordinating Center for TrialNet since October, 2008. The primary objective of TrialNet is to
prevent or delay initial onset and/or progression of type 1 diabetes (T1D) by preserving insulin-
producing beta cells in individuals at elevated risk and those who have been newly diagnosed
with T1DM. To achieve this goal, TrialNet designs and implements prevention and
interventional clinical trials intended to test treatments that may preserve remaining insulin
secretion in recently diagnosed individuals (new-onsets). The TNCC provides epidemiological,
biostatistical, operational and administrative expertise and advice to the clinical centers,
reference laboratories and the NIDDK which include the following tasks: 1) study-wide
communications, procurement and dissemination of study materials, and related activities 2)
data management and records maintenance; 3) clinical site and central laboratories monitoring;
4) data analyses; 5) preparation of study reports and papers for publication; 6) implementation
of procedures to evaluate management, methodology, and cost-effectiveness of procedures
utilized by the TNCC. This application provides support for the design and conduct of
prevention and recent onset trials. It provides for continued support for TrialNet and the many
ongoing projects focused on the identification of individuals at risk and their enrollment on
TrialNet studies.

## Key facts

- **NIH application ID:** 10385660
- **Project number:** 3U01DK106993-04S1
- **Recipient organization:** UNIVERSITY OF SOUTH FLORIDA
- **Principal Investigator:** JEFFREY P KRISCHER
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $15,000,000
- **Award type:** 3
- **Project period:** 2015-09-30 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10385660

## Citation

> US National Institutes of Health, RePORTER application 10385660, Revision to the Coordinating Center for Type 1 Diabetes TrialNet (3U01DK106993-04S1). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10385660. Licensed CC0.

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